Kinetic study of ruthenium(III) catalyzed oxidation of proline by bromate in acidic medium
Kinetic investigation on ruthenium(III) catalyzed oxidation of proline by acidic solution of potassium bromate in the presence of mercuric acetate as a scavenger for Br- ion has been made in the temperature range 30-45°. The rate shows zero order kinetics in bromate [BrO3 -], but order of reaction is one with respect to the substrate and [RuIII] respectively. Increase in [Cl-] showed positive effect, while increase in [H+] showed negative effect. Negligible effect of mercuric acetate and ionic strength of the medium is observed. A transient complex, formed between [RuCl6]3- and amino acid ([RuCl6]3- being reactive species of ruthenium(III) chloride) in 1:1 ratio, disproportionates in a slow and rate-determining step. Various activation parameters have been calculated. A suitable mechanism has been proposed.
Srivastava, Sheila,Singh, Sarika
p. 295 - 298
(2007/10/03)
Production of L-Tryptophan from γ-Glutamaldehydic Acid
Labile γ-glutamaldehydic acid (I) was first converted to tryptophan via its phenylhydrazone; no racemization occured during the reaction.The stability of 1 was shown to be remarkably enhanced in the presence of additives.