- Bromination products of morphine
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Morphine (1) reacts with an excess of bromine to yield 6-acetoxy-1,2- dibromomorphine (3), while in hydrobromic acid with bromine the isomeric 1,2,7 α,8β- and 1,2,7β,8α-tetrabromomorphines 4 and 5 are obtained. NMR data show that ring C exists as a chair conformation in 4 and has a boat conformation in 5.
- Goerlitzer,Weltrowski,Wray,Schumann
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p. 655 - 657
(2007/10/03)
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