cas 497839-62-0, AEE788 | Articles data

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2,6-DICHLORO-8-IODO-7-DEAZAPURINE FOR SYNTHESIZING POLYSUBSTITUTED 7-DEAZAPURINE DERIVATIVE
PROBLEM TO BE SOLVED: To overcome many times and labors needed for synthesizing various polysubstituted 7-deazapurine derivatives which is expected usefulness or the like as pharmaceutical because they are conventionally synthesized through several synthetic routes depending on kinds and positions of substituents. SOLUTION: Used is 2,6-dichloro-8-iodo-7-deazapurine represented by the following formula (1) available as a key intermediate of polysubstituted 7-deazapurine derivatives. Predetermined substituents can be introduced to 8-, m6- and 2-positions respectively in this order, therefor it is useful as an intermediate for synthesizing targeted polysubstituted 7-deazapurine derivative. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
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(2017/01/31)

ORGANIC COMPOUNDS
The present invention provides highly efficient methods for the preparation of {6-[4- (4-ethyl-piperazin-1-ylmethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-((R)-1-phenyl-ethyl)- amine.
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Page/Page column 7-8

(2010/11/25)

7H-pyrrolo[2,3-d]pyrimidine derivatives
The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.
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(2008/06/13)

Chemical Properties

Boiling Point: 639.246 °C at 760 mmHg
Flash Point:340.404 °C
Density: 1.204 g/cm³
Solubility:≥22.05 mg/mL in DMSO; insoluble in H2O; ≥14.4 mg/mL in EtOH with ultrasonic
Storage Temp.:-20°C
PSA: 63.31000
LogP: 4.23320

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Chemical Properties

Boiling Point: 639.246 °C at 760 mmHg

Flash Point:340.404 °C

Density: 1.204 g/cm³

Solubility:≥22.05 mg/mL in DMSO; insoluble in H2O; ≥14.4 mg/mL in EtOH with ultrasonic

Storage Temp.:-20°C

PSA: 63.31000

LogP: 4.23320

Global suppliers and manufacturers of 497839-62-0total 52 suppliers on LookChem

Article Database

497839-62-0

Articles about 497839-62-0Total 3 be found

More Articles about upstream products of 497839-62-0

Chemical Properties

Boiling Point: 639.246 °C at 760 mmHg

Flash Point:340.404 °C

Density: 1.204 g/cm3

Solubility:≥22.05 mg/mL in DMSO; insoluble in H2O; ≥14.4 mg/mL in EtOH with ultrasonic

Storage Temp.:-20°C

PSA: 63.31000

LogP: 4.23320

Global suppliers and manufacturers of 497839-62-0total 52 suppliers on LookChem

Density: 1.204 g/cm³