Tetrahydroquinoline sulfonamides as γ-secretase inhibitors
The development of a novel series of tetrahydroquinoline-derived γ-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
Asberom, Theodros,Bara, Thomas A.,Clader, John W.,Greenlee, William J.,Guzik, Henry S.,Josien, Hubert B.,Li, Wei,Parker, Eric M.,Pissarnitski, Dmitri A.,Song, Lixin,Zhang, Lili,Zhao, Zhiqiang
p. 205 - 207
(2007/10/03)
Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors
γ-Secretase is a key enzyme involved in the production of β-amyloid peptides which are believed to play a critical role in the onset and progression of Alzheimer's disease (AD). As such, inhibition of γ-secretase has been an attractive approach to AD ther
Guo, Tao,Gu, Huizhong,Hobbs, Doug W.,Rokosz, Laura L.,Stauffer, Tara M.,Jacob, Biji,Clader, John W.
p. 3010 - 3013
(2008/02/05)
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