- A One-Step, Atom Economical Synthesis of Thieno[2,3-d]pyrimidin-4-amine Derivatives by a Four-Component Reaction
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A Na2HPO4-catalyzed four-component reaction between a ketone, malononitrile, S8 and formamide has been realized for the first time. This reaction provides a concise approach to thieno[2,3-d]pyrimidin-4-amines, previously r
- Shi, Taoda,Zerio, ChristopherJ.,Sivinski, Jared,Ambrose, Andrew J.,Moore, Kohlson T.,Buckley, Thomas,Kaneko, Lynn,Zhang, Mae,Zhang, Donna D.,Chapman, Eli
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supporting information
p. 3269 - 3272
(2019/05/29)
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- Efficient constructions of the four different thienopyrimidinone skeletons via various cyclocondensation of o-aminothienonitrile with carbonyl compounds
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A series of new thienopyrimidinone derivatives were synthesized via a novel, straightforward and efficient tandem cyclocondensation of o-aminothienonitrile 1 and carbonyl compounds 2 in different conditions. The synthesized four thienopyrimidinone skeleto
- Yang, Junjuan,Shi, Daxin,Zhang, Kai,Zhao, Zhangtao,Qiu, Fadong,Bi, Yujiao,Zhang, Qi,Li, Jiarong
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p. 866 - 885
(2016/07/06)
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- Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors
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4-Aminobenzothieno[3,2-d]pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5,6-substituted 4-aminothieno[2,3-d] pyrimidines with low micromolar inhibition of LIMK1.
- Sleebs, Brad E.,Nikolakopoulos, George,Street, Ian P.,Falk, Hendrik,Baell, Jonathan B.
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p. 5992 - 5994
(2011/10/18)
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- Synthesis of 5-thioxo-hexahydrobenzo[b]thiopheno[2,3-d]-1,2,4-triazolo[1,5- c]pyrimidines and related compounds based on cyclocondensations of 2-isothiocyanato-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene
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5-Thioxo-4,6,8,9,10,11-hexahydro-benzo[b]thiopheno[2,3-d]-1,2,4-triazolo[1, 5-c]pyrimidines and related compounds were prepared based on cyclizations of 2-isothiocyanato-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene with aminoketones and carboxylic hydrazid
- Pfeiffer, Wolf-Diethard,Dollinger, Horst,Langer, Peter
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experimental part
p. 626 - 637
(2009/11/30)
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- Synthesis and antimicrobial activity of some tetramethylenethieno[2,3-d]pyrimidine derivatives
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A series of tetramethylenethieno[2,3-d]pyrimidine derivatives has been synthesized and tested for its antimicrobial properties. All the synthesized compounds were found to exhibit in vitro antibacterial and/or antifungal activity. The highest activity was elicited by 4-benzolhydrazino-5,6-tetramethylenethieno[2,3-d]pyrimidine (9) showing MIC value of 7.81 μg/ml against E. coli and C. albicans, while its MBC value was half that of nystatin. Compound 16 was almost as potent as nystatin exhibiting a minimum bactericidal concentration (MBC) value of 15.62 μg/ml.
- Ismail,Aboulwafa,Koreish
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p. 611 - 616
(2007/10/03)
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