- Dehalogenation methodof 9-halogenated steroid compound and application
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The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.
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Paragraph 0164-0166
(2021/01/11)
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- Preparation process of hydrocortisone acetate
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The invention relates to a preparation process of hydrocortisone acetate. The preparation process comprises the following steps: under the action of 4-dimethylamiopryidine, enabling hydrocortisone and acetic anhydride to directly react, without the need of additionally utilizing a solvent; washing into water and separating out materials; filtering and drying to prepare the hydrocortisone acetate. The technical problem in the prior art that a reaction process commonly needs pyridine or a pyridine substitute solvent is overcome; the large-batch production capability of a reaction kettle is greatly improved and a condition that a lot of industrial wastewater difficult to treat is generated is avoided. The preparation process has a simple process, is good for environment protection, is low in cost and is suitable for industrial large-scale production.
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Paragraph 0015
(2017/07/06)
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- 9α-dehalogenation process
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The present invention involves improved processes for the dehalogenation of 9α-halosteroids (I) STR1 to produce the corresponding 11β-hydroxy steroids (II) STR2 which are known to be useful as pharmaceutical, where the improvements comprise (1) adding the 9α-halo steroid (I) to the chromium and (2) using catalytic amounts of chromium in the presence of a means of converting chromium (II) to chromium (III).
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