Camptothecin derivatives as chemoradiosensitizing agents
Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.
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Page/Page column 35
(2008/06/13)
Application of NMR Spectroscopy of Chiral Association Complexes. 13.Electron Donor-acceptor Complexes between Racemic Carbazolocarbazoles and an Optically Active Acceptor
Strong electron donor-acceptor (EDA) asociation between carbazolocarbazoles and an optically active tetranitrofluorenone derivative was detected by UV-visible spectroscopy and by 1H NMR shifts. 1H NMR splitting at low temperatures are due ti diastereomeric association complexes and, thus, prove the chirality of carbazolocarbazoles.
Icli, Siddik,Burgemeister, Thomas,Mannschreck, Albrecht,Zander, Maximilian
p. 145 - 150
(2007/10/02)
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