- Facilitated photochemical cleavage of benzylic C-O bond. Application to photolabile hydroxyl-protecting group design
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A new photolabile hydroxyl-protecting group has been developed by introducing a dimethylamino group to the meta position of an aromatic ring of the traditional trityl (Tr) protecting group. The Royal Society of Chemistry 2010.
- Wang, Pengfei,Zhou, Lei,Zhang, Xin,Liang, Xing
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scheme or table
p. 1514 - 1516
(2010/06/12)
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- PHOTO-ACTIVATED PROTECTING GROUPS
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Novel photo-activated protecting groups, photo-activatable groups, and methods for their synthesis and use are described. The photo-activated protecting groups are useful in making photo-activatable forms, i.e., inactive proforms, of compounds that can be activated in situ, for example, for initiating chemical reactions upon photo-activation or providing an inactive proform of a therapeutic agent to a subject and photo-activating the therapeutic agent at a selected area of the subject. Also disclosed are methods for administering a photo-activatable compound to a subject then activating the compound at a selected area of the subject by exposing that area to light.
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Page/Page column 28
(2010/04/28)
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- Synthesis of spirobicyclic peptides on a solid support
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The spirobicyclic peptides 2-6 were synthesized as stereoisomeric pairs using an orthogonally protected bis(aminomethyl)malonic acid building block 1 as the branching unit. Peptide 2 was synthesized by two methods. Either the chain assembly and first cyclization were carried out on a Wang resin, and the second cyclization in solution (Scheme 1), or the whole synthesis was performed on a solid-supported backbone amide linker derived from 4-alkoxybenzaldehyde (Scheme 3). The applicability of the latter method was further evaluated by synthesis of four additional spirobicyclic peptides 3-6.
- Virta, Pasi,Sinkkonen, Jari,Loennberg, Harri
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p. 3616 - 3621
(2007/10/03)
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