- Dimethylmalonyltrialkylphosphoranes: Probing the steric effect on phosphorus and its stereochemical consequence in esterification reactions of chiral secondary alcohols
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High chemical yields and high levels of stereochemical inversion are demonstrated in the phosphorane-mediated esterification reaction of chiral alcohols with non-hindered carboxylic acids through the incorporation of sterically non-hindered alkyl groups o
- Dyck,Zavorine,Robertson,Capretta,Larichev,Britten,McNulty
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- PHOSPHORANES AS COUPLING AGENTS AND THEIR PREPARATION
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Provided is a use as a coupling agent for condensation reactions of a compound of formula (I): wherein each of R1, R2, and R3 is independently H, hydrocarbyl, or hydrocarbyloxy, provided that not more than one of R1, R2, and R3 is H ; and at least one of Y1 and Y2 is an electron-withdrawing group and the other, if not an electron-withdrawing group, is H or a group that has no electron-donating properties, with the proviso that when one of Y1 and Y2 is H, the other is not -CN. Some of the compounds of formula (I) are novel, and methods of their preparation are also provided.
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