cas 5022-65-1, H-TRP-NH2 HCL | Articles data ｜lookchem

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5022-65-1

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MODIFIED PEPTIDES FOR USE IN TREATING NEURODEGENERATIVE DISORDERS
The invention relates to neurodegenerative disorders, and in particular to novel peptides, peptidomimetics, compositions, therapies and methods for treating such conditions, for example Alzheimer's disease.
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Page/Page column 50

(2018/03/09)

A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues
A facile route has been established for the synthesis of indole-substituted (S)-tryptophans from corresponding indoles, which utilizes a chiral auxiliary-facilitated Strecker amino acid synthesis strategy. The chiral auxiliary reagents evaluated were (S)-methylbenzylamine and related derivatives. To illustrate the robustness of the method, eight optically pure (S)-tryptophan analogues were synthesized, which were subsequently used for the convergent synthesis of a potent antibacterial agent, argyrin A and its analogues.
Chen, Chou-Hsiung,Genapathy, Sivaneswary,Fischer, Peter M.,Chan, Weng C.
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p. 9764 - 9768
(2015/01/09)

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.
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Page/Page column 45-49; 60

(2010/12/31)

New active series of growth hormone secretagogues
New growth hormone secretagogue (GHS) analogues were synthesized and evaluated for growth hormone releasing activity. This series derived from EP-51389 is based on a gem-diamino structure. Compounds that exhibited higher in vivo GH-releasing potency than hexarelin in rat (subcutaneous administration) were then tested per os in beagle dogs and for their binding affinity to human pituitary GHS receptors and to hGHS-R 1a. Compound 7 (JMV 1843, H-Aib-(D)-Trp-(D)-gTrp-formyl) showed high potency in these tests and was selected for clinical studies.
Guerlavais, Vincent,Boeglin, Damien,Mousseaux, Delphine,Oiry, Catherine,Heitz, Annie,Deghenghi, Romano,Locatelli, Vittorio,Torsello, Antonio,Ghé, Corrado,Catapano, Filomena,Muccioli, Giampiero,Galleyrand, Jean-Claude,Fehrentz, Jean-Alain,Martinez, Jean
p. 1191 - 1203
(2007/10/03)

Dichlorotris(dimethylamino)phosphorane as a Dehydratisation Reagent for the Preparation of N-Protected Amino Acid Amides
Besides for the synthesis of peptides and activated esters dichlorotris(dimethylamino)phosphorane (2) now proved to be an excellent reagent for the preparation of N-protected amino acid amides.
Appel, Rolf,Hiester, Ernst
p. 2037 - 2040
(2007/10/02)

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Chemical Properties

Melting Point: 250 °C
Boiling Point: 498.7°Cat760mmHg
Flash Point:255.4°C
Density: g/cm³
Solubility:Methanol, Water
Storage Temp.:2-8°C
Vapor Pressure: 4.44E-10mmHg at 25°C
Refractive Index: 25 ° (C=1, H2O)
PSA: 159.50000
LogP: 1.07920

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