- Facile preparation and synthetic applications of LiCH2C(CF3)2Oli
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Bromohydrin BrCH2C(CF3)2OH readily reacts with two equivalents of n-BuLi at - 78 °C to produce the corresponding dilithium derivative LiCH2C(CF3)2OLi in high yield. This dilithiated derivative reacts selectively, acting as a C-nucleophile, with a variety of electrophiles such as R2PCl, carbonyl compounds, and epoxides, to give electron-deficient phosphines R2PCH2C(CF3)2OH, 1,3- and 1,4-diols, correspondingly.
- Grushin, Vladimir V.,Marshall, William J.,Halliday, Gary A.,Davidson, Fredric,Petrov, Viacheslav A.
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p. 121 - 129
(2007/10/03)
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