Pd-Catalyzed P–C Cross-Coupling of Aryl Bromides and Triflates with Hydroxymethylphosphine Sulfide Derivatives
The development of a versatile process for phosphine synthesis has attracted considerable interest because organophosphines are indispensable for organic synthesis. Previously, we developed a Pd-catalyzed P–C coupling reaction for hydroxymethylphosphine s
Ohta, Hidetoshi,Xue, Qian,Hayashi, Minoru
supporting information
p. 735 - 738
(2018/02/21)
Pd-catalyzed P-C cross-coupling reactions for versatile triarylphosphine synthesis
Practical and versatile syntheses of tertiary phosphine derivatives have been achieved by palladium-catalyzed deformylative P-C cross-coupling reactions of hydroxymethylphosphine derivatives. Sequential couplings of orthogonally protected precursors provide a simple and practical route toward a variety of tertiary phosphine derivatives having aryl substituents in any combination.