Series of aminopyridinecarboxamide-based inhibitors were synthesized and tested against human recombinant IKK-2 and in IL-1β stimulated synovial fibroblasts. The 2-amino-5-chloropyridine-4-carboxamides were identified as the most potent inhibitors with im
Bonafoux, Dominique F.,Bonar, Sheri L.,Clare, Michael,Donnelly, Ann M.,Glaenzer, Jeanette L.,Guzova, Julia A.,Huang, He,Kishore, Nandidni N.,Koszyk, Francis J.,Lennon, Patrick J.,Libby, Adam,Mathialagan, Sumathy,Oburn, David S.,Rouw, Sharon A,Sommers, Cynthia D.,Tripp, Catherine S.,Vanella, Lori J.,Weier, Richard,Wolfson, Serge G.,Huang, Horng-Chih
experimental part
p. 403 - 414
(2010/03/25)
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