- Light-Driven Carboxylation of o-Alkylphenyl Ketones with CO2
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o-Alkylphenyl ketones undergo a C-C bond forming carboxylation reaction with CO2 simply upon irradiation with UV light or even solar light. The reaction presents a clean process exploiting light energy as the driving force for carboxylation of organic molecules with CO2.
- Masuda, Yusuke,Ishida, Naoki,Murakami, Masahiro
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supporting information
p. 14063 - 14066
(2015/11/25)
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- BIPHENYL INTEGRIN ANTAGONISTS
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The following invention is directed to pharmaceutical compounds and compositions of the Formula (I). useful for treating conditions mediated by αVβ3 and/or αVβ5 integrin.
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Page/Page column 35-36
(2010/11/08)
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- Reactions of carbonyl compounds in basic solutions. Part 21. The mechanisms of the alkaline hydrolysis of substituted methyl 2-(2-oxopropyl)- and 2-(2-oxo-2-phenylethyl)-benzoates and 2-(2-acetylphenyl)- and 2-(2-benzoylphenyl)-acetates
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Rate coefficients have been measured for the alkaline hydrolysis of methyl 2-[2-oxo-2-(3- or 4-substituted phenyl)ethyl]benzoates, 2-[2-(3- or 4-substituted benzoyl)phenyl]acetates,2-(2-oxopropyl) and 2-(1,1-dimethyl-2- oxopropyl)benzoates, 2-(2-acetylphenyl)acetate and 2-(2-acetylphenyl)-2,2- dimethylacetates in 70% (v/v) dioxane-water at 30.0 °C. Those for the six parent esters were also measured at 45.0 and 60.0 °C and the enthalpies and entropies of activation have been evaluated. The relative rates of hydrolysis, activation parameters and substituent effects have been used to demonstrate neighbouring participation by the keto-carbonyl groups in the alkaline hydrolysis of the esters under study. For comparable systems, participation by six-membered ring intermediates appears somewhat less advantageous than five-membered.
- Bowden, Keith,Byrne, Jane M.
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p. 2203 - 2206
(2007/10/03)
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- 2-(Arylmethyl)arylacetic Acids as Potential Antiinflammatory Agents
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The title compounds 2 have been synthesized and tested for antiinflammatory activity.The synthetic method, consisting of the chemical sequence 3-aryl-1H-indenes (4) 2-(aroyl)arylacetic acids (5) 2, appears to be of value because of its simplicity
- Brancaccio, Giovanni,Larizza, Angelo,Lettieri, Guglielmo,Monforte, Pietro
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p. 998 - 1000
(2007/10/02)
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