- Clay catalyzed synthesis of imines and enamines under solvent-free conditions using microwave irradiation
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The reactions of primary and secondary amines with aldehydes and ketones, respectively, are accelerated by microwaves under solvent-free conditions in the presence of montmorillonite K 10 clay to afford a high yield synthesis of imines and enamines.
- Varma, Rajender S.,Dahiya, Rajender,Kumar, Sudhir
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p. 2039 - 2042
(2007/10/03)
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- Synthesis of Enamines from Cycloalkanones and Secondary Cyclic Amines using K-10 Montmorillonite Clay
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The synthesis of enamines from cycloalkanones and secondary cyclic amines has been carried out in 85-95percent yield in the presence of K-10 montmorrilonite clay and with azeotropic removal of the water formed in the condensation.
- Dewan, Sharwan K.,Varma, Urmila,Malik, Shiv Darshan
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- REGIOSPECIFIC SYNTHESIS OF α-ARYLSULFONOXY KETONES FROM KETONE DERIVATIVES
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Isomeric enol ester, enamine, and silyl enol ether derivatives of unsymmetrical ketones are converted regiospecifically to α-arylsulfonoxy ketones with arylsulfonyl peroxides.
- Hoffman, Robert V.,Carr, C. Sean
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p. 5811 - 5812
(2007/10/02)
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- Enamines of 3,3-Dimethylazetidine
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In an improvement over previous procedures, 3,3-dimethylazetidine (3) has been synthesized in 26percent yield from ethyl cyanoacetate.Rates of formation for the enamines of 3 and of pyrrolidine with 2-methylcyclohexanone (1) and 1-tetralone (2) have been studied.The 5- to 10-fold rate increase observed for 3 is attributed to diminished steric hindrance relative to pyrrolidine.Compared to the enamines of pyrrolidine with 1 and 2, those of 3 methylate initially on nitrogen to ggreater degree and are less selective for monomethylation.The enamine formed between 1 and 3 exists at equilibrium as an 83.17 mixture of tri- and tetrasubstituted isomers, in which the less substituted isomer has its vinyl H 1H NMR peak at δ 4.10.These properties are compared to those of other enamines of 1, in which a predictive relationship had previously been suggested.
- Thompson, Hugh W.,Swistok, Joseph
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p. 4907 - 4911
(2007/10/02)
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