- Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions
-
Being able to utilize a protecting group to influence remote regiocontrol offers a simple alternative approach to direct late-stage functionalization of complex organic molecules. However, protecting groups that have the ability to influence reaction regi
- Brittain, William D. G.,Cobb, Steven L.
-
-
Read Online
- Photocatalytic Oxidative Iodination of Electron-Rich Arenes
-
A visible-light-mediated oxidative iodination of electron-rich arenes has been developed. 2.5 mol% of unsubstituted anthraquinone as photocatalyst were used in combination with elementary iodine, trifluoroacetic acid and oxygen as the terminal oxidant. The iodination proceeds upon irradiation in non- or weakly-electron donating solvents (DCM, DCE and benzene) wherein a spectral window in strongly coloured iodine solutions can be observed at around 400 nm. The method provides good to excellent yields (up to 98%) and shows excellent regioselectivity and good functional group tolerance (triple bonds, ketone, ester, amide). Moreover, the photo-iodination was also upscaled to a 5 mmol scale (1.1 g). Mechanistic investigations by intermediate trapping and competition experiments indicate a photocatalytic arene oxidation and the subsequent reaction with iodine as a likely mechanistic pathway. (Figure presented.).
- Narobe, Rok,Düsel, Simon J. S.,Iskra, Jernej,K?nig, Burkhard
-
supporting information
p. 3998 - 4004
(2019/07/17)
-
- Facile and practical synthesis of π-extended oxepins by benzannulation and intramolecular cyclization
-
π-Extended oxepins 1 and dimer 8 were synthesized by the benzannulation of the corresponding asymmetric diarylacetylene derivatives and 2-(phenylethynyl)benzaldehyde followed by the Cu-catalyzed intramolecular cyclization. The optical properties of the π-extended oxepins 1 and 8 are also investigated.
- Umeda, Rui,Shimizu, Yuji,Ida, Yuta,Ikeshita, Masahiro,Suzuki, Shuichi,Naota, Takeshi,Nishiyama, Yutaka
-
p. 183 - 186
(2018/12/11)
-
- One-pot ortho-amination of aryl C-H bonds using consecutive iron and copper catalysis
-
A one-pot approach for ortho-coupling of arenes with non-actived N-nucleophiles has been developed using sequential iron and copper catalysis. Regioselective ortho-activation of anisoles, anilines and phenols was achieved through iron(iii) triflimide catalysed iodination, followed by a copper(i)-catalysed, ligand-assisted coupling reaction with N-heterocycle, amide and sulfonamide-based nucleophiles. The synthetic utility of this one-pot, two-step method for the direct amination of ortho-aryl C-H bonds was demonstrated with the late-stage functionalisation of 3,4-dihydroquinolin-2-ones. This allowed the preparation of a TRIM24 bromodomain inhibitor and a series of novel analogues.
- Henry, Martyn C.,McGrory, Rochelle,Faggyas, Réka J.,Mostafa, Mohamed A. B.,Sutherland, Andrew
-
p. 4629 - 4639
(2019/05/17)
-
- Transition-Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings
-
Constructing products of high synthetic value from inexpensive and abundant starting materials is of great importance. Aryl iodides are essential building blocks for the synthesis of functional molecules, and efficient methods for their synthesis from chemical feedstocks are highly sought after. Here we report a low-cost decarboxylative iodination that occurs simply from readily available benzoic acids and I2. The reaction is scalable and the scope and robustness of the reaction is thoroughly examined. Mechanistic studies suggest that this reaction does not proceed via a radical mechanism, which is in contrast to classical Hunsdiecker-type decarboxylative halogenations. In addition, DFT studies allow comparisons to be made between our procedure and current transition-metal-catalyzed decarboxylations. The utility of this procedure is demonstrated in its application to oxidative cross-couplings of aromatics via decarboxylative/C-H or double decarboxylative activations that use I2 as the terminal oxidant. This strategy allows the preparation of biaryls previously inaccessible via decarboxylative methods and holds other advantages over existing decarboxylative oxidative couplings, as stoichiometric transition metals are avoided.
- Perry, Gregory J. P.,Quibell, Jacob M.,Panigrahi, Adyasha,Larrosa, Igor
-
supporting information
p. 11527 - 11536
(2017/08/30)
-
- A one-pot radioiodination of aryl amines: Via stable diazonium salts: Preparation of 125I-imaging agents
-
An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of 125I-labelled aryl compounds and SPECT radiotracers.
- Sloan, Nikki L.,Luthra, Sajinder K.,McRobbie, Graeme,Pimlott, Sally L.,Sutherland, Andrew
-
supporting information
p. 11008 - 11011
(2017/10/13)
-
- Late stage iodination of biologically active agents using a one-pot process from aryl amines
-
A simple and effective one-pot tandem procedure that generates aryl iodides from readily available aryl amines via stable diazonium salts has been developed. The operationally simple procedure and mild conditions allow late-stage iodination of a wide range of aryl compounds bearing various functional groups and substitution patterns. A novel synthetic strategy involving the preparation of nitroaryl compounds followed by a chemoselective tin(ii) dichloride reduction and the use of the one-pot diazotisation-iodination transformation was also developed. The general applicability of this approach was demonstrated with the preparation of a number of medicinally important compounds including CNS1261, a SPECT imaging agent of the N-methyl-d-aspartate (NMDA) receptor and IBOX, a compound used to detect amyloid plaques in the brain.
- Sloan, Nikki L.,Luthra, Sajinder K.,McRobbie, Graeme,Pimlott, Sally L.,Sutherland, Andrew
-
p. 54881 - 54891
(2017/12/12)
-
- N-Iodosuccinimide (NIS) in Direct Aromatic Iodination
-
N-Iodosuccinimide (NIS) in pure trifluoroacetic acid (TFA) offers a time-efficient and general method for the iodination of a wide range of mono- and disubstituted benzenes at room temperature, as demonstrated in this paper. The starting materials were generally converted into mono-iodinated products in less than 16 hours at room temperature, without byproducts. A few deactivated substrates needed addition of sulfuric acid to increase the reaction rate. Another exception was methoxybenzenes that preferentially were iodinated by NIS in acetonitrile with only catalytic amounts of TFA.
- Bergstr?m, Maria,Suresh, Ganji,Naidu, Veluru Ramesh,Unelius, C. Rikard
-
p. 3234 - 3239
(2017/06/21)
-
- Site-Selective Copper-Catalyzed Amination and Azidation of Arenes and Heteroarenes via Deprotonative Zincation
-
Arene amination is achieved by site-selective C-H zincation followed by copper-catalyzed coupling with O-benzoylhydroxylamines under mild conditions. Key to this success is ortho-zincation mediated by lithium amidodiethylzincate base that is effective for a wide range of arenes, including nonactivated arenes bearing simple functionalities such as fluoride, chloride, ester, amide, ether, nitrile, and trifluoromethyl groups as well as heteroarenes including indole, thiophene, pyridine, and isoquinoline. An analogous C-H azidation is also accomplished using azidoiodinane for direct introduction of a useful azide group onto a broad scope of arenes and heteroarenes. These new transformations offer rapid access to valuable and diverse chemical space of aminoarenes. Their broad applications in organic synthesis and drug discovery are demonstrated in the synthesis of novel analogues of natural product (-)-nicotine and antidepressant sertraline by late-stage amination and azidation reactions.
- Hendrick, Charles E.,Bitting, Katie J.,Cho, Seoyoung,Wang, Qiu
-
supporting information
p. 11622 - 11628
(2017/08/30)
-
- An in situ acidic carbon dioxide/glycol system for aerobic oxidative iodination of electron-rich aromatics catalyzed by Fe(NO3)3·9H2O
-
An environmentally benign CO2/glycol reversible acidic system was developed for the iron(iii)-catalyzed aerobic oxidative iodination of electron-rich aromatics without the need for any conventional acid additive or organic solvent. Notably, moderate to high isolated yields (up to 97%) of the aryl iodides were attained with comparable regioselectivity when ferric nitrate nonahydrate was used as the catalyst with molecular iodine under 1 MPa of CO2.
- Ma, Ran,Huang, Cheng-Bin,Liu, An-Hua,Li, Xue-Dong,He, Liang-Nian
-
p. 4308 - 4312
(2015/01/08)
-
- Nitrogen dioxide-catalyzed electrophilic iodination of arenes
-
Nitrogen dioxide is demonstrated to be an effective catalyst precursor for the iodination of alkoxy-substituted benzenes and naphthalenes. Different from the transition metal catalysts, nitrogen dioxide can be easily separated from the final products, and is free of heavy metal waste. Although the present catalyst precursor is toxic, it does not stain the final products due to its low-boiling character. No other reagents apart from 0.5 equiv. of iodine (I 2), 6.5 mol% nitrogen dioxide and acetonitrile solvent were used in the iodination, and basically all the iodine atoms in the iodine source were transferred to the iodination products, showing that the presented protocol is highly atom-economic and practical. Copyright
- Ren, Yun-Lai,Shang, Huantao,Wang, Jianji,Tian, Xinzhe,Zhao, Shuang,Wang, Qian,Li, Fuwei
-
supporting information
p. 3437 - 3442
(2013/12/04)
-
- Regioselective iodination of aromatic compounds with potassium iodide in the presence of benzyltriphenylphosphonium perchlorate
-
A simple and efficient method for the selective iodination of various aromatic compounds by using potassium iodide in the presence of benzyltriphenylphosphonium perchlorate, is reported. This method provides several advantages such as good selectivity between ortho and para positions of aromatic compounds and high yields of the products.
- Albadi, Jalal,Abedini, Masoumeh,Iravani, Nasir
-
experimental part
p. 261 - 264
(2012/05/07)
-
- METHOD OF PRODUCING IODIZING AGENT, AND METHOD OF PRODUCING AROMATIC IODINE COMPOUND
-
A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.
- -
-
Page/Page column 12
(2010/05/13)
-
- Mild arming and derivatization of natural products via an In(OTf) 3-catalyzed arene iodination
-
Figure presented Iodination of arene-containing natural products employing N-iodosuccinimide catalyzed by In(OTf)3 at ambient temperature is reported as a versatile and mild method for natural product derivatization amenable to small scale. This process facilitates natural product derivatization of arene moieties for SAR studies, homo- and heterodimerization of natural products, and also conjugation with reporters such as biotin via subsequent metal-mediated coupling reactions.
- Zhou, Cong-Ying,Li, Jing,Peddibhotla, Satyamaheshwar,Romo, Daniel
-
supporting information; experimental part
p. 2104 - 2107
(2010/09/15)
-
- An efficient and regioselective iodination of electron-rich aromatic compounds using N-chlorosuccinimide and sodium iodide
-
An efficient and regioselective method for iodination of electron-rich aromatic compounds was found using N-chlorosuccinimide and sodium iodide in AcOH with short reaction times. This method is also applicable to non-benzenoid aromatic or heteroaromatic c
- Yamamoto, Takuya,Toyota, Kozo,Morita, Noboru
-
experimental part
p. 1364 - 1366
(2010/05/03)
-
- Practical electrochemical iodination of aromatic compounds
-
A practical method for electrochemical iodination of aromatic compounds was developed. The method involves the generation of I+ by electrochemical oxidation of I2 in CH3CN using H 2SO4 as supporting electrolyte followed by the reaction with aromatic compounds. The para/ortho selectivity for the reaction of mono-substituted benzenes was significantly improved using dimethoxyethane as cosolvent in the second step. The reaction with highly reactive aromatic compounds led to the formation of significant amounts of diiodo compounds in a macrobatch reactor. This problem was solved by fast 1:1 mixing of I+ with an aromatic compound using a microflow system consisting of a T-shaped micromixer and a microtube reactor.
- Kataoka, Kazuhide,Hagiwara, Yuji,Midorikawa, Koji,Suga, Seiji,Yoshida, Jun-Ichi
-
p. 1130 - 1136
(2013/01/03)
-
- Iodination of activated aromatic compounds using sodium peroxodisulfate and iodine: An efficient way to iodinate alkylated calix[4]arenes
-
A simple method for the iodination of activated arenes, using molecular iodine and sodium peroxodisulfate as the oxidant, is presented. The reaction is conducted in the presence of catalytic amounts of tetramethylammonium iodide as a phase-transfer catalyst in acetonitrile. For non-polar substances, which are not soluble in pure acetonitrile such as calix[4]arenes bearing long alkyl chains, a modified reaction is introduced. In this case the phase-transfer catalyst is changed to methyltriphenylphosphonium peroxodisulfate. Chloroform as a cosolvent mediates solubility. Furthermore, we show that the slightly basic conditions obtained upon the addition of sodium bicarbonate have a beneficial effect on the yield. Georg Thieme Verlag Stuttgart.
- Barton, Olaf G.,Mattay, Jochen
-
p. 110 - 114
(2008/09/20)
-
- A mild and simple regioselective iodination of activated aromatics with iodine and catalytic ceric ammonium nitrate
-
Molecular iodine in the presence of a catalytic amount of CAN has been utilized efficiently for regioselective iodination of activated aromatic compounds under mild reaction conditions.
- Das, Biswanath,Krishnaiah, Maddeboina,Venkateswarlu, Katta,Reddy, V. Saidi
-
-
- Simple method for the introduction of iodo-label on (3-trifluoromethyl) phenyldiazirine for photoaffinity labeling
-
A simple and mild method was developed for the introduction of iodo-label on (3-trifluoromethyl) phenyldiazirine (TPD) aromatic ring in the presence of three membered diazirine ring. An iodination protocol, I2-BTI in CH3CN, was found
- Hashimoto, Makoto,Kato, Yuhi,Hatanaka, Yasumaru
-
p. 3391 - 3394
(2007/10/03)
-
- One-pot preparation of arylalkynes by a tandem catalytic iodination of arenes and palladium-catalyzed coupling of iodoarenes with terminal alkynes
-
Iodination of activated arenes by air-oxidation is carried out in the presence of catalytic bismuth salts at room temperature. Subsequently, the formed iodoarenes react with terminal alkynes to give arylalkynes under a selected palladium-catalyzed coupling condition in the same pot.
- Wan, Shun,Wang, Sunewang R.,Lu, Wenjun
-
p. 4349 - 4352
(2007/10/03)
-
- Practical and regioselective halogenations of aromatic compounds using tetrabutylammonium peroxydisulfate
-
The halogenated aromatic compounds have been important intermediates for various synthetic methods. Electron-rich aromatic compounds were easily iodinated using tetrabutylammonium peroxydisulfate (1) and iodine in mild conditions with excellent yields. Bromination was achieved using 1 and bromine, and regioselective bromination of highly activated aromatic compounds was also achieved using 1 and lithium bromide in mild conditions with excellent yields. Copyright Taylor & Francis Inc.
- Min, Young Park,Seung, Gak Yang,Kim, Yong Hae
-
p. 1235 - 1240
(2007/10/03)
-
- Regioselective iodination of activated arenes using phenyl trimethylammonium dichloroiodate in ionic liquid under microwave irradiation
-
The regioselective iodination of activated arenes has been achieved in the presence of phenyltrimethylammonium dichloroiodate and ionic liquid. The reaction has been carried out by both conventional heating as well as by microwave irradiation. Copyright Taylor & Francis, Inc.
- Tilve, Rutuja D.,Kanetkar, Vinod R.
-
p. 1313 - 1318
(2007/10/03)
-
- Effective and regioselective iodination of arenes using iron(III) nitrate in the presence of tungstophosphoric acid
-
An easy, cheap, and effective method for iodination of various aromatic compounds takes place with molecular iodine and iron nitrate nonahydrate as the oxidant in the presence of a catalytic amount of tungstophosphoric acid in dichloromethane, with good yield and high regioselectivity under very mild conditions.
- Jafarzadeh, Mohammad,Amani, Kamal,Nikpour, Farzad
-
p. 1808 - 1811
(2007/10/03)
-
- Simple and regioselective oxyiodination of aromatic compounds with ammonium iodide and Oxone
-
Oxyiodination of aromatic compounds using NH4I and Oxone gives high yields and selectivity. A simple method for the iodination of aromatic compounds using NH4I as the iodine source and Oxone as the oxidant is described.
- Krishna Mohan,Narender,Kulkarni
-
p. 8015 - 8018
(2007/10/03)
-
- Solvent-Free Iodination of Arenes at Room Temperature
-
Silica supported bismuth(III)nitrate pentahydrate [BNP-SiO2] was prepared under simple co-grinding condition. The iodination of aromatic compounds using BNP-SiO2 and molecular iodine under solvent-free conditions is described. The reaction occurred in the solid state at room temperature, yielding the corresponding mono-iodo derivative in good yields. However, less activated aromatics required longer reaction time with comparatively less yield.
- Alexander, Varughese M.,Khandekar, Amit C.,Samant, Shriniwas D.
-
p. 1895 - 1897
(2007/10/03)
-
- An Efficient, Catalytic, Aerobic, Oxidative Iodination of Arenes Using the H5PV2Mo10O40 Polyoxometalate as Catalyst
-
Iodination of arenes was carried out by reacting 1 equiv of arene substrate with 0.5 equiv of iodine under an oxygen atmosphere with H 5PV2Mo10O40 as oxidation catalyst. The synthesis is an inherently waste-free method for the preparation of iodoarenes.
- Branytska, Olena V.,Neumann, Ronny
-
p. 9510 - 9512
(2007/10/03)
-
- Direct and regioselective iodination and bromination of benzene, naphthalene and other activated aromatic compounds using iodine and bromine
-
Direct and regioselective iodination and bromination of benzene, naphthalene and other activated aromatic compounds with iodine and bromine or their sodium salts proceed well in the presence of Fe(NO3) 3·1.5N2O4/charcoal in CH 2Cl2 at room temperature.
- Firouzabadi,Iranpoor,Shiri
-
p. 8781 - 8785
(2007/10/03)
-
- Iodination of activated arenes using silfen: An improved protocol
-
A simple and direct method for the iodination of activated arenes, using molecular iodine and silfen (silica supported ferric nitrate nonahydrate) as an oxidant, is presented. The reactions are performed at 20°C in dichloromethane. The method provides an easy access to the corresponding iodinated products in good yields. The observed orientation effects are in agreement with those based on general aromatic electrophilic substitution theory.
- Tilve, Rutuja D.,Alexander, Varughese M.,Khadilkar, Bhushan M.
-
p. 9457 - 9459
(2007/10/03)
-
- A practical iodination of aromatic compounds using tetrabutylammonium peroxydisulfate and iodine
-
A variety of aromatic compounds substituted with an electron donating group such as methoxy, hydroxy, or amino group, were regioselectively iodinated with iodine in the presence of tetrabutylammonium peroxydisulfate under mild conditions in excellent yields.
- Yang, Seung Gak,Kim, Yong Hae
-
p. 6051 - 6054
(2007/10/03)
-
- Iodothyronine Deiodinase Mimics. Deiodination of o,o'-Diiodophenols by Selenium and Tellurium Reagents
-
To better understand, and in the extension mimic, the action of the three selenium-containing iodothyronine deiodinases, o,o'-diiodophenols were reacted under acidic conditions with sodium hydrogen telluride, benzenetellurol, sodium hydrogen selenide, or benzeneselenol and under basic conditions with the corresponding deprotonated reagents. Sodium hydrogen telluride was found to selectively remove one iodine from a variety of 4-substituted o,o'-diiodophenols, including a protected form of thyroxine (T4). Thus, it mimics the D1 variety of the iodothyronine deiodinases. Sodium telluride was a more reactive deiodinating agent toward o,o'-diiodophenols, often causing removal of both halogens. Benzenetellurol and sodium benzenetellurolate sometimes showed useful selectivity for monodeiodination. However, the products were often contaminated by small amounts of organotellurium compounds. Sodium hydrogen selenide, sodium selenide, benzeneselenol, and sodium benzeneselenolate were essentially unreactive toward o,o'-diiodophenols. To gain more insight into thyroxine inner-ring deiodination, substituted 2,6-diiodophenyl methyl ethers were treated with some of the chalcogen reagents. Reactivity and selectivity for monodeiodination varied considerably depending on the substituents attached to the aromatic nucleus. In general, it was possible to find reagents that could bring about the selective mono- or dideiodination of these substrates.
- Vasil'ev, Andrei A.,Engman, Lars
-
p. 3911 - 3917
(2007/10/03)
-
- Mild and regiospecific nuclear iodination of methoxybenzenes and naphthalenes with N-iodosuccinimide in acetonitrile
-
A wide range of methoxy substituted benzenes and naphthalenes were regiospecifically iodinated at para position with N-iodosuccinimide in acetonitrile under mild conditions in excellent yields. Methylanisoles afforded only nuclear iodination products.
- Carreno, M. Carmen,Garcia Ruano, Jose L.,Sanz, Gema,Toledo, Miguel A.,Urbano, Antonio
-
p. 4081 - 4084
(2007/10/03)
-
- Iodination of alkyl aryl ethers by mercury(II) oxide-iodine reagent in dichloromethane
-
A convenient method for selective mono- and diiodination of alkyl aryl ethers by mercury(II) oxide-iodine reagent in dichloromethane is reported.
- Orito,Hatakeyama,Takeo,Suginome
-
p. 1273 - 1277
(2007/10/02)
-
- Cation Radicals as Intermediates in Aromatic Halogenation with Iodine Monochloride: Solvent and Salt Effects on the Competition between Chlorination and Iodination
-
Three distinct classes of substitutional reactivity can be discerned in the halogenation of a series of methyl-substituted methoxybenzenes (ArH) with iodine monochloride (ICl), namely, exclusive iodination, exclusive chlorination, and mixed iodination/chlorination.Spectral studies establish the prior formation of the charge-transfer complex which suffers electron transfer to afford the reactive triad .+,I.,Cl(-)> according to Scheme 1.Separate reactivity studies show that chlorination and iodination can result from the quenching of the aromatic cation radical by chloride and iodine (atom), respectively.Iodination versus chlorination thus represents the competition between radical-pair and ion-pair collapse from the reactive triad, and it is predictably modulated by solvent polarity and added salt.
- Hubig, S. M.,Jung, W.,Kochi, J. K.
-
p. 6233 - 6244
(2007/10/02)
-
- Nitrone Cycloaddition: An Approach to the Cyclophane Alkaloid (+/-)-Lythranidine
-
The synthesis of (+/-)-lythranidine 1, a cyclophane alkaloid from Lythrum anceps Makino, involves three interesting problems.These are the construction of the 17-membered ring, the formation of the trans-2,6-dialkylpiperidine and the establishment of the
- Carruthers, William,Coggins, Peter,Weston, John B.
-
p. 611 - 616
(2007/10/02)
-
- Iodination of Aromatic Ethers by Use of Benzyltrimethylammonium Dichloroiodate and Zinc Chloride
-
The reaction of aromatic ethers with benzyltrimethylammonium dichloroiodate(1-) in acetic acid in the presence of zinc chloride at room temperature gave iodo-substituted aromatic ethers in good yields.
- Kajigaeshi, Shoji,Kakinami, Takaaki,Moriwaki, Masayuki,Watanabe, Masakazu,Fujisaki, Shizuo,Okamoto, Tsuyoshi
-
p. 795 - 798
(2007/10/02)
-
- Process for producing iodo-aromatic compounds
-
In a process for producing an iodo-aromatic compound which comprises iodinating an aromatic compound having an electron-donating substituent bonded to the benzene ring with iodine in the presence of a solvent, the improvement wherein about 1/2 to about 10 moles, per mole of iodine added to the reaction system, of nitrogen dioxide (NO2) is added in the form of NO2 to the reaction system, and the reaction is carried out in the presence of nitrogen dioxide.
- -
-
-
- Electron Transfer Mechanism for Periodic Acid Oxidation of Aromatic Substrates
-
Evidence for the involvement of cation radicals during the periodic acid oxidation of aromatic substrates like hydrocarbons, phenolic ethers, phenols etc. has been presented.
- Bhatt, M. V.,Hosur, B. M.
-
p. 1004 - 1005
(2007/10/02)
-
- Synthesis and Characterisation of 2-Iodo-4phenol(iodoHoechst 33258) and 2,5-Disubstituted Benzimidazole Model Compounds
-
The product of iodination of the DNA-binding dye Hoechst 33258, 4-phenol (1), has been identified as the monoiodo derivative, i.e. 2-iodo-4-5''-(4'''-methylpiperazin-1'''-yl)-2'',5'-bi-1
- Martin, Roger F.,Pardee, Marshall,Kelly, David P.,Mack, Philip O.-L.
-
p. 373 - 381
(2007/10/02)
-