- Synthesis of Lichesterol
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Ergosta-5,8(9),22-trien-3β-ol has been synthesized and its identity with lichesterol has been confirmed.Ergosteryl acetate was transformed into 7α-ergosta-5,8(9),22-trien-3β-yl acetate which was converted into lichesterol by reduction with lithium in ethylamine.
- Anastasia, Mario,Fiecchi, Alberto
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- Phycomysterols and other sterols from the Fungus phycomyces blakesleeanus
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In the search for novel bioactive products from filamentous fungi, sterols and triterpenoids found in Phycomyces blakesleeanus were analyzed using semipreparative HPLC, GC-MS, and NMR techniques. Structures proposed for the three new compounds identified, phycomysterol A (1), phycomysterol B (2), and neoergosterol (3), were confirmed by chemical synthesis. Phycomysterols possess a new natural 19-norergostane skeleton with an aromatic B ring. Phycomysterol A showed anti-HIV activity.
- Barrero,Enrique Oltra,Poyatos,Jimenez,Oliver
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p. 1491 - 1496
(2007/10/03)
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- EFFECT ON ERGOSTEROL BIOSYNTHESIS OF A FUNGICIDE, SSF-109, IN BOTRYTIS CINEREA
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Treatment of Botrytis cinerea with a novel fungicide SSF-109, (dl)-cis-1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclo-heptanol (0.45 μg ml-1), gave five 14α-methyl sterols, 24-methylene-24(25)-dihydrolanosterol, 24-methylene-24(25)-dihydrolanosten-3-one, obtusifoliol, obtusifolione, and 14α-methylfecosterol, together with ergosterol and ergosta-5,8,22-trien-3β-ol.SSF-109 was found to inhibit the biosynthesis of ergosterol at the 14α-demethylation step.
- Shirane, Noboru,Murabayashi, Akira,Masuko, Michio,Uomori, Atsuko,Yoshimura, Yohko,et al.
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p. 2513 - 2520
(2007/10/02)
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