- Synthesis of Spiro[benzofuran-2,2'-benzo[b]thiophene]-3,3'-diones via PIDA/CuBr-Mediated Spirocyclization
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A phenyliodine(III) diacetate (PIDA)/CuBr-mediated construction of the novel 3H,3'H-spiro[benzofuran-2,2'-benzo[b]thiophene]-3,3'-dione skeleton was realized from the reaction of (Z)-3-hydroxy-1-(2-hydroxyphenyl)-3-(2-halogenphenyl)prop-2-en-1-ones with p
- Du, Yunfei,Li, Xuemin,Liang, Huiyuan,Sun, Fengxia,Wang, Donghua,Wang, Xi,Yang, Yaxin O,Zhang, Jingran
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p. 6563 - 6569
(2020/11/16)
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- Synthesis and biological evaluation of 2-acylbenzofuranes as novel α-glucosidase inhibitors with hypoglycemic activity
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A series of benzofuran derivatives was synthesized as analogues of known natural α-glucosidase inhibitors. Their activity was evaluated in enzymatic assay and in rat model of diabetes mellitus. Newly identified inhibitors demonstrate significant potency with IC50 values ranging from 6.50 to 722.2?μm, as well as hypoglycemic activity exceeding the reference drug acarbose. Docking simulations provided insight into structure-activity relationships to direct further development of these novel hypoglycemic agents.
- Spasov, Alexander A.,Babkov, Denis A.,Prokhorova, Tatyana Yu,Sturova, Ekaterina A.,Muleeva, Diana R.,Demidov, Maxim R.,Osipov, Dmitry V.,Osyanin, Vitaly A.,Klimochkin, Yuri N.
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p. 1184 - 1189
(2017/10/06)
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- Microwave-assisted Dieckmann reaction: Efficient one-step synthesis of 2-aroylbenzofuran-3-ols
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This paper describes the first efficient one-step synthesis of 2-aroylbenzofuran-3-ols from the microwave-assisted Dieckmann reaction of substituted methylsalicylates with 2-bromo-1-aroylethanones in alkaline aprotic solvents. This method features excelle
- Zhou, Zhong-Zhen,Deng, Yan-Hong,Jiang, Zhi-Hong,Chen, Wen-Hua
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supporting information; experimental part
p. 1909 - 1913
(2010/11/03)
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- BENZOFURANS AND BENZOTHIOPHENES
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The invention relates to compounds of the general formula (I), in which R1, R2, R3, R4, R5, R6 and X are as defined in Claim 1. These compounds can be used in the treatment of pathologies associated with insulin resistance syndrome.
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Page/Page column 18; 35
(2010/02/12)
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- Oxidation of α-Benzoyl-o-hydroxyacetophenones Using Iodobenzene Diacetate in Methanolic Potassium Hydroxide: A New Synthesis of 2-Benzoylcoumaran-3-ones
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The oxidation of α-benzoyl-o-hydroxyacetophenones (3a-d) using iodobenzene diacetate in methanolic potassium hydroxide provides a new direct method for the synthesis of 2-benzoylcoumaran-3-ones (4a-d) in good yields.The formation of 4a-d is explained by n
- Prakash, Om,Goyal, Seema,Pahuja, Saroj,Singh, Shiv P.
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p. 1409 - 1415
(2007/10/02)
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