- ERYTHROMYCIN AS A SUPRAMOLECULAR RECEPTOR
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When Erythromycin A (E) is added to a solution of Rhodamine B base (Z) dissolved in chloroform, dioxane or DMSO the color disappears immediately and this effect is attributed to the formation of a Host-Guest complex between Z and E followed by a fast lactonization of Z.
- Barra, Monica,Rossi, Rita H. de
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- CONTACT-KILLING, QAC FUNCTIONALIZED THERMOPLASTIC POLYURETHANE FOR CATHETER APPLICATIONS
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In various embodiments, the present invention provides a functionalized thermoplastic polyurethane (TPU) containing bulk incorporated or surface-grafted quaternary ammonium compounds (QAC)s for contact-killing of a variety of microbes, where the QACs are on the surface of TPU to provide a sterile surface material that prevents bacteria commonly involved in device-associated infections (DAIs) from proliferating. The functionalized TPUs of the present invention can be formed into a wide variety of 3-dimensional shapes, such as catheters, medical tubing, laryngeal or tracheal stents, sutures, prosthetics, wound dressings, and/or a coating for medical devices and contains the residue of either a QAC containing diol monomer or an alkene functional diol monomer, which then allows the TPU to be functionalized with a QAC containing disulfide or free thiol compound, to form a quaternary ammonium functionalized thermoplastic polyurethane compound having antimicrobial properties for use in medical devices.
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Paragraph 0262
(2019/04/25)
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- Fluorescent probes based on O-glycoside, and synthetic methods and application thereof
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The invention discloses fluorescent probes based on O-glycoside, and synthetic methods and application thereof. The fluorescent probes are prepared through four-step reactions, and the synthetic methods have the characteristics of usage of cheap and easily available reaction raw materials, few reaction steps, high yield, etc. The invention discloses a plurality of purposes of the fluorescent probes based on O-glycoside, including 1, detection of iron ions on the basis of the characteristic that the fluorescent probes are of spiro structures and have no fluorescence, but emits strong red fluorescence after addition of iron ions; 2, detection of a Job's Plot curve which is utilized for analyzing the bonding ratios of the probes to iron ions; and 3, ionic competition experiments, which are used for detection of the competitiveness of the probes in the presence of a plurality of other common cations.
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Paragraph 0033-0036
(2018/05/16)
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- Docetaxel-Loaded Fluorescent Liquid-Crystalline Nanoparticles for Cancer Theranostics
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Here, we describe a novel monoolein-based cubosome formulation engineered for possible theranostic applications in oncology. The Docetaxel-loaded nanoparticles were stabilized in water by a mixture of commercial Pluronic (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer) F108 (PF108) and rhodamine- and folate-conjugated PF108 so that the nanoparticles possess targeting, therapeutic, and imaging properties. Nanoparticles were investigated by DLS, cryo-TEM, and SAXS to confirm their structural features. The fluorescent emission characterization of the proposed formulation indicated that the rhodamine conjugated to the PF108 experiences an environment less polar than water (similar to chloroform), suggesting that the fluorescent fragment is buried within the poly(ethylene oxide) corona surrounding the nanoparticle. Furthermore, these nanoparticles were successfully used to image living HeLa cells and demonstrated a significant short-term (4 h incubation) cytotoxicity effect against these cancer cells. Furthermore, given their analogy as nanocarriers for molecules of pharmaceutical interest and to better stress the singularities of these bicontinuous cubic nanoparticles, we also quantitatively evaluated the differences between cubosomes and multilamellar liposomes in terms of surface area and hydrophobic volume.
- Meli, Valeria,Caltagirone, Claudia,Falchi, Angela M.,Hyde, Stephen T.,Lippolis, Vito,Monduzzi, Maura,Obiols-Rabasa, Marc,Rosa, Antonella,Schmidt, Judith,Talmon, Yeshayahu,Murgia, Sergio
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p. 9566 - 9575
(2015/09/15)
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- A dual functional probe for "turn-on" fluorescence response of Pb2+ and colorimetric detection of Cu2+ based on a rhodamine derivative in aqueous media
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A dual functional probe L based on rhodamine was devised and synthesized. Probe L can sense Pb2+ and Cu2+ in aqueous solution through two approaches: a significant fluorescence enhancement caused by Pb2+ and a visible color change from colorless to orchid induced by Cu2+. Competitive experiments showed that probe L had high fluorescence sensitivity for Pb2+ and excellent colorimetric selectivity for Cu2+ over many environmentally relevant ions. The mechanisms of L for sensing Pb2+ and Cu2+ have been well demonstrated by ESI-MS, 1H NMR titration, IR, the crystal structure of L-Pb2+ and density functional theory calculation of L-Cu2+. In addition, fluorescence image detection of Pb2+ in living cells displayed an enhanced fluorescence effect.
- Li, Min,Jiang, Xiu-Juan,Wu, Hui-Hui,Lu, Hong-Lin,Li, Hai-Yang,Xu, Hong,Zang, Shuang-Quan,Mak, Thomas C. W.
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p. 17326 - 17334
(2015/10/12)
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- Novel malachite green- and rhodamine B-labeled cationic chain transfer agents for RAFT polymerization
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Two novel cationic RAFT agents have been synthesized, one labeled with a Malachite Green (MG) dye and another with a Rhodamine B (RhoB) dye. MG-labeled dithiobenzoate (MGEDBA) was prepared in a straightforward manner after synthesis of MG-ethylammonium chloride that reacted with a precursor dithiobenzoate bearing an activated ester function. However, the analogous reaction with RhoB amino derivative led to a mixture of dithiobenzoate and thioamide derivatives. An alternative approach yielded the RhoB-labeled RAFT agent (RhoBEDBA) with complete conversion. The purification of these dye-labeled RAFT agents was very challenging because of their dual nature (aromatic and ionic). Both MGEDBA and RhoBEDBA were efficient RAFT chain transfer agents to control the polymerization of N,N-dimethylacrylamide (DMA). The resulting α-end-labeled MG- and RhoB-PDMA samples presented low dispersities (1.2) and both chain-ends were preserved. Finally, we showed that the attachment of RhoB and MG to the PDMA polymer chain-end did not influence the photophysical properties of these dyes. Therefore, these new dye-labeled RAFT agents can be used to prepare various labeled polymers and especially water-soluble ones, to study their conformation and dynamics in solution or at interfaces using fluorescence methods, or as labeled probes for imaging and/or diagnosis purposes.
- Beija, Mariana,Afonso, Carlos A.M.,Farinha, José Paulo S.,Charreyre, Marie-Thérse,Martinho, José M.G.
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experimental part
p. 5933 - 5946
(2012/04/10)
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- Ionization and Tautomerism of Hydroxyxanthenes and Some Other Dyes in Ethanol
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Protolytic equilibria of hydroxyxanthene dyes, Fluorescein and Eosin, as well as of some related compounds, in ethanol were studied by spectrophotometry. Stepwise ionization and tautomeric equilibrium constants were determined.
- Mchedlov-Petrosyan
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p. 267 - 274
(2007/10/03)
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- Practical synthetic route to functionalized rhodamine dyes
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(Matrix presented) An efficient method for the synthesis of functionalized rhodamine derivatives has been developed. Multigram quantities of these water-soluble fluorophores can be prepared from inexpensive precursors and purified without the use of chromatography. A series of protein-reactive functional groups has been installed through subsequent reactions, providing materials for biomolecule modification. For multicolor applications, a solid-phase purification strategy has been developed to afford rhodamine derivatives possessing a wide range of spectral properties.
- Nguyen, Trung,Francis, Matthew B.
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p. 3245 - 3248
(2007/10/03)
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- Pressure Effects on Equilibrium between Lactone and Zwitterion Forms of Rhodamine B in Primary Alcohols
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The equilibrium between lactone and zwitterion forms of Rhodamine B was studied in primary alcohols and at high pressures.The effects of solvent polarity and pressure on the equilibrium constant were examined by using a Kirkwood-type equation.
- Sueishi, Yoshimi,Sugiyama, Yukie,Yamamoto, Shunzo,Nishimura, Norio
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p. 572 - 574
(2007/10/02)
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- Erythromycin A as a Supramolecular Catalyst: Effect on Rhodamine B Lactonization
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The intramolecular lactonization reaction of rhodamine B base in chloroform solution is remarkably accelerated by the antibiotic erythromycin A.The rate increases by a factor of ca. 1010, a value significantly higher than typical enzymatic factors.This effect is ascribed to the formation of a host-guest complex between the dye and the antibiotic, a process that induces a conformational change conducive to the rehybridization of the central carbon atom of the dye.
- Barra, Monica,Cosa, Juan Jose,Rossi, Rita H. de
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p. 5850 - 5853
(2007/10/02)
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- Aspectroscopic/thermodynamic study of the rhodamine B lactone ->/<- zwitterion equilibrium
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Temperature dependences of the visible absorption spectra of rhodamine B (RB) in water and 18 alcohol solvents have been examined and utilized to estimate thermodynamic parameters (ΔG0, ΔH0, ΔS0) for the RB lactone->///3/mol*cm is estimated.The thermodynamic results suggest that the position of the RB L ->/- Z equilibrium is strongly influenced by self-association of the solvent.The position of the equilibrium in aliphatic alcohols can be predicted from the simple features of the solvent molecules.Consequences of the results regarding calculation of the natural radiative lifetime of the fluorescent state from absorption spectrum are discussed.
- Hinckley, Daniel A.,Seybold, Paul G.
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p. 1053 - 1060
(2007/10/02)
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