- Non-Cryogenic, Ammonia-Free Reduction of Aryl Compounds
-
A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from ?20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety.
- -
-
-
- Chlorotrimethylsilane and Sodium Iodide: A Remarkable Metal-Free Association for the Desulfurization of Benzylic Dithioketals under Mild Conditions
-
A novel metal-free process allowing the reductive desulfurization of various benzylic dithioketals to afford diarylmethane and benzylester derivatives with good to excellent yields is reported. At room temperature, this mild reduction process requires only the use of TMSCl and NaI in CH2Cl2 and tolerates a large variety of functional groups. (Figure presented.).
- Zhao, Guangkuan,Yuan, Ling-Zhi,Alami, Mouad,Provot, Olivier
-
p. 2522 - 2536
(2018/05/14)
-
- Mild Deoxygenation of Aromatic Ketones and Aldehydes over Pd/C Using Polymethylhydrosiloxane as the Reducing Agent
-
Herein, a practical and mild method for the deoxygenation of a wide range of benzylic aldehydes and ketones is described, which utilizes heterogeneous Pd/C as the catalyst together with the green hydride source, polymethylhydrosiloxane. The developed catalytic protocol is scalable and robust, as exemplified by the deoxygenation of ethyl vanillin, which was performed on a 30 mmol scale in an open-to-air setup using only 0.085 mol% Pd/C catalyst to furnish the corresponding deoxygenated product in 93% yield within 3 hours at room temperature. Furthermore, the Pd/C catalyst was shown to be recyclable up to 6 times without any observable decrease in efficiency and it exhibited low metal leaching under the reaction conditions.
- Volkov, Alexey,Gustafson, Karl P. J.,Tai, Cheuk-Wai,Verho, Oscar,B?ckvall, Jan-E.,Adolfsson, Hans
-
supporting information
p. 5122 - 5126
(2015/04/27)
-
- Efficient palladium-catalyzed C-O hydrogenolysis of benzylic alcohols and aromatic ketones with polymethylhydrosiloxane
-
A simple method has been developed for the reductive deoxygenation of aromatic ketones and benzylic alcohols in the presence of polymethylhydrosiloxane (PMHS). The reductive deoxygenation of aromatic ketones and benzylic alcohols, including secondary alcohols, to the corresponding methylene hydrocarbons has been achieved in good to excellent yields using palladium chloride (PdCl2) as catalyst and PMHS as hydride source. Such deoxygenations were successfully with aryl alkyl ketones and diaryl ketones, as exemplified by the reductive deoxygenation of acetophenone and benzopheneone, respectively. The corresponding benzylic alcohols and secondary alcohol analogues could also be converted into their respective methylene hydrocarbons by the PdCl2/PMHS system.
- Wang, Hu,Li, Li,Bai, Xing-Feng,Shang, Jun-Yan,Yang, Ke-Fang,Xu, Li-Wen
-
supporting information
p. 341 - 347
(2013/05/08)
-
- One-by-one hydrogenation, cross-coupling reaction, and Knoevenagel condensations catalyzed by PdCl2 and the downstream palladium residue
-
A novel catalyst-economic strategy with a recovered palladium catalyst was successfully applied for multi-task and maximum reuse in different types of one-by-one downstream reactions, from catalytic hydrogenation to Suzuki and Sonogashira-type cross-coupling reactions, Knoevenagel condensations, and trans-Knoevenagel-like condensations.
- Wang, Hu,Li, Li,Bai, Xing-Feng,Deng, Wen-Hui,Zheng, Zhan-Jiang,Yang, Ke-Fang,Xu, Li-Wen
-
supporting information
p. 2349 - 2355
(2013/09/12)
-
- AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY
-
The present invention relates to aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminoindane derivatives, and the use of such aminoindane derivatives for therapeutic purposes. The aminoindane derivatives are GlyT1 inhibitors.
- -
-
Page/Page column 95-96
(2012/03/08)
-
- Converting a birch reduction product into a polyketide: Application to the synthesis of a C1-C11 building block of rimocidin
-
A stereoselective synthesis of a C1-C11 building block for the polyol-polyene antibiotic rimocidin has been developed. Its functional groups originate from a disubstituted indane, which underwent Birch reduction, and oxidative cleava
- Nachbauer, Luc,Brueckner, Reinhard
-
p. 6904 - 6923
(2013/02/23)
-
- Tridemethylisovelleral, a potent cytotoxic agent
-
The synthesis and in vitro cytotoxicity toward various tumor cell lines of (±)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2- dicarbaldehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral.
- Aujard, Isabelle,Roeme, Daniel,Arzel, Erwan,Johansson, Martin,De Vos, Dick,Sterner, Olov
-
p. 6145 - 6150
(2007/10/03)
-
- Process for preparing a 2,3-dihydro-1H-imidazolyl-ethoxy indene antithrombotic agent and its pharmaceutically acceptable salts
-
A process is disclosed for preparing a 2,3-dihydro-1H-imidazolylethoxy indene antithrombotic agent and its pharmaceutically acceptable salts.
- -
-
-