- TRIAZOLE DERIVATIVE
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A compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof has an effect of inhibiting binding between S1P and its receptor Edg-1(S1P1), and is useful as a pharmaceutical product. (I) (In the formula, A represents a sulfur atom, an oxygen atom, a formula -SO- or a formula -SO2-; R1 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms or the like; R2 represents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-8 carbon atoms or the like; R3 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, a phenyl group or the like; R5 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms; and R6 represents an alkyl group having 1-6 carbon atoms, a phenyl group or a substituted phenyl group.)
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Page/Page column 21-22
(2008/06/13)
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- Squaric acid derivatives prevent the removal of N-Cbz and N-Fmoc groups under catalytic hydrogenation reaction
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Under the catalytic hydrogenation conditions (H2/Pd-C), squaric acid derivatives 4 and 7 were found to be effective additives for chemoselective reduction of olefins and an alkyne having an N-Cbz or N-Fmoc group where the amino group remained to be protected. Benzyl esters having an N-Cbz or N-Fmoc group we re also selectively removed to give the corresponding N-protected carboxylic acids.
- Shinada,Hayashi,Yoshida,Ohfune
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p. 1506 - 1508
(2007/10/03)
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- A Facile Synthesis of α-Amino Esters via Reduction of α-Nitro Esters Using Ammonium Formate as a Catalytic Hydrogen Transfer Agent
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Various nitroesters 3 were selectively and rapidly reduced to their corresponding amino esters 4 in very good yield using anhydrous ammonium formate as a catalytic hydrogen transfer agent.
- Ram, Siya,Ehrenkaufer, Richard E.
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p. 133 - 135
(2007/10/02)
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