- TRIAZOLE AGONISTS OF THE APJ RECEPTOR
-
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures where the definitions of the variables are provided herein.
- -
-
Paragraph 0343; 0344
(2016/12/07)
-
- BENZENE SULFONAMIDES AS CCR9 INHIBITORS
-
The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD).
- -
-
Page/Page column 100
(2015/07/15)
-
- Benzamides
-
The present invention is directed to benzamide containing compounds which inhibit the P2X7 receptor
- -
-
Paragraph 0123
(2014/05/07)
-
- High-throughput virtual screening identifies novel N ′-(1- phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors
-
Lysine specific demethylase 1 (LSD1) plays an important role in regulating histone lysine methylation at residues K4 and K9 on histone H3 and is an attractive therapeutic target in multiple malignancies. Here we report a structure-based virtual screen of
- Sorna, Venkataswamy,Theisen, Emily R.,Stephens, Bret,Warner, Steven L.,Bearss, David J.,Vankayalapati, Hariprasad,Sharma, Sunil
-
p. 9496 - 9508
(2014/01/06)
-
- SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS
-
In one aspect, the invention relates to substituted (E)-N'-(1- phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods fo
- -
-
Page/Page column 93
(2013/03/26)
-
- THERAPEUTIC SUBSTITUTED CYCLOPENTANES FOR REDUCING INTRAOCULAR PRESSURE
-
Disclosed herein are compounds having formula (I) wherein a dashed line represents the presence or absence of a bond; Y is an organic acid functional group, or an amide or ester thereof; or Y is hydroxymethyl or an ether thereof; or Y is a tetrazolyl func
- -
-
Page/Page column 27-28
(2009/03/07)
-
- Selective alkoxycarbonylation of 2,3-dichloropyridines
-
2,3-Dichloropyridines undergo a motto- or a dicarbonylation in the presence of carbon monoxide, an alcohol and a palladium catalyst, affording selectively either alkyl 3-chloropicolinates, or dialkyl pyridine-2,3- dicarboxylates in good yields, depending on the reaction conditions.
- Bessard, Yves,Roduit, Jean Paul
-
p. 393 - 404
(2007/10/03)
-
