Design, synthesis, and biological evaluation of novel human 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP) substrates
The structure-based design, chemical synthesis, and biological evaluation of novel MTAP substrates are described. These compounds incorporate various C5′-moieties and are shown to have different kcat/Km values compared with the natural MTAP substrate (MTA).
Kung, Pei-Pei,Zehnder, Luke R.,Meng, Jerry J.,Kupchinsky, Stanley W.,Skalitzky, Donald J.,Johnson, M. Catherine,Maegley, Karen A.,Ekker, Anne,Kuhn, Leslie A.,Rose, Peter W.,Bloom, Laura A.
p. 2829 - 2833
(2007/10/03)
Nucleic acid related compounds. 66. Improved synthese of 5'-chloro-5'-deoxy- and 5'-S-aryl(or alkyl)-5'-thionucleosides
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Robins,Hansske,Wnuk,Kanai
p. 1468 - 1474
(2007/10/02)
Fluorination at C5' of nucleosides, synthesis of the new class of 5'-fluoro-5'-S-aryl (alkyl) thionucleosides from adenosine
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Robins,Wnuk
p. 5729 - 5732
(2007/10/02)
On the thio ether and S-oxide derivatives of adenosine
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Kuhn,Jahn
p. 1699 - 1704
(2007/10/04)
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