- A Highly Selective Na2WO4-Catalyzed Oxidation of Terpenic Alcohols by Hydrogen Peroxide
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Sodium tungstate was found to be an active and highly selective catalyst to oxidation of various primary or secondary origin renewable alcohols by hydrogen peroxide as green oxidant. Borneol, nerol, geraniol and β-citronellol were efficiently and selectively converted to respective carbonyl derivatives by hydrogen peroxide. ATR/FT-IR measurements confirmed that Na2W(O2)4 was the specie active catalytically. The role of the main reaction variables, including temperature, reactants and catalyst concentration, solvent, and nature of substrate were also assessed. In addition to use a green oxidant, this simple and environmentally friendly catalyst system did not require additive to control pH, molecular sieves or phase transfer catalyst. Graphical Abstract: [Figure not available: see fulltext.].
- Viana, Luna Andrade Silva,da Silva, Giovanna Rodrigues Nobile,da Silva, Márcio Jose
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p. 374 - 382
(2017/12/04)
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- Mechanistic insight into aerobic alcohol oxidation using NOx-nitroxide catalysis based on catalyst structure-activity relationships
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The mechanism of an NOx-assisted, nitroxide(nitroxyl radical)-catalyzed aerobic oxidation of alcohols was investigated using a set of sterically and electronically modified nitroxides (i.e., TEMPO, AZADO (1), 5-F-AZADO (2), 5,7-DiF-AZADO (3), 5-MeO-AZADO (4), 5,7-DiMeO-AZADO (5), oxa-AZADO (6), TsN-AZADO (7), and DiAZADO (8)). The motivation for the present study stemmed from our previous observation that the introduction of an F atom at a remote position from the nitroxyl radical moiety on the azaadamantane nucleus effectively enhanced the catalytic activity under typical NOx-mediated aerobic-oxidation conditions. The kinetic profiles of the azaadamantane-N-oxyl-[AZADO (1)-, 5-F-AZADO (2)-, and 5,7-DiF-AZADO (3)]-catalyzed aerobic oxidations were closely investigated, revealing that AZADO (1) showed a high initial reaction rate compared to 5-F-AZADO (2) and 5,7-DiF-AZADO (3); however, AZADO-catalyzed oxidation exhibited a marked slowdown, resulting in ~90% conversion, whereas 5-F-AZADO-catalyzed oxidation smoothly reached completion without a marked slowdown. The reasons for the marked slowdown and the role of the fluoro group are discussed. Oxa-AZADO (6), TsN-AZADO (7), and DiAZADO (8) were designed and synthesized to confirm their comparable catalytic efficiency to that of 5-F-AZADO (2), providing supporting evidence for the electronic effect on the catalytic efficiency of the heteroatoms under NOx-assisted aerobic-oxidation conditions.
- Shibuya, Masatoshi,Nagasawa, Shota,Osada, Yuji,Iwabuchi, Yoshiharu
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p. 10256 - 10268
(2015/02/19)
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- Chloroform as a hydrogen atom donor in barton reductive decarboxylation reactions
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The utility of chloroform as both a solvent and a hydrogen atom donor in Barton reductive decarboxylation of a range of carboxylic acids was recently demonstrated (Ko, E. J. et al. Org. Lett. 2011, 13, 1944). In the present work, a combination of electronic structure calculations, direct dynamics calculations, and experimental studies was carried out to investigate how chloroform acts as a hydrogen atom donor in Barton reductive decarboxylations and to determine the scope of this process. The results from this study show that hydrogen atom transfer from chloroform occurs directly under kinetic control and is aided by a combination of polar effects and quantum mechanical tunneling. Chloroform acts as an effective hydrogen atom donor for primary, secondary, and tertiary alkyl radicals, although significant chlorination was also observed with unstrained tertiary carboxylic acids.
- Ho, Junming,Zheng, Jingjing,Meana-Paneda, Ruben,Truhlar, Donald G.,Ko, Eun Jung,Savage, G. Paul,Williams, Craig M.,Coote, Michelle L.,Tsanaktsidis, John
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p. 6677 - 6687
(2013/07/26)
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- Transition metal-mediated oxidations utilizing monomeric iodosyl- and iodylarene species
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Several transition metal-mediated oxidations using hypervalent iodine species are reported. A convenient procedure for preparation of iodylarenes via RuCl3-catalyzed oxidation of iodoarenes has been developed. This procedure allows the generation of highly reactive monomeric iodine(V) species, which are excellent oxidants toward alcohols and hydrocarbons in situ. A broad range of substrates can be oxidized to carbonyl compounds by a tandem catalytic system based on the Ru(III)-catalyzed reoxidation of ArIO to ArIO2 using Oxone as oxidant. It was shown that electrophilic iodine(III) species, originating from oligomeric iodosylbenzene sulfate (PhIO)3SO3, are efficient oxygenating agents in catalytic oxidation of aromatic hydrocarbons in the presence of metalloporphyrin complexes.
- Yusubov, Mekhman S.,Nemykin, Victor N.,Zhdankin, Viktor V.
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experimental part
p. 5745 - 5752
(2010/10/02)
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- Iodine(V)/ruthenium(III)-cocatalyzed oxidations: A highly efficient tandem catalytic system for the oxidation of alcohols and hydrocarbons with oxone
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An extremely mild and efficient tandem catalytic system for the oxidation of alcohols and hydrocarbons based on Ru(III)-catalyzed reoxidation of ArIO to ArIO2 was reported, by using Oxone as a stoichiometric oxidant. Oxone was added to a mixture of propylbenzene, PhI, and RuCl3 in acetonitrile and water in five portions over 22 h under stirring at room temperature. The reaction mixture was stirred for an additional 4 h and was monitored by TLC by the disappearance of propylbenzene. Then ethyl acetate and water were added and the mixture was stirred for 5 mm. The organic solution was separated and the aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed with NaCl, and dried over Na2SO 4. The oxidation of the other hydrocarbons was performed by using a similar procedure. The use of smaller amounts of Oxone led to incomplete conversion owing to its noticeable decomposition with loss of oxygen gas under reaction conditions.
- Yusubov, Mekhman S.,Zagulyaeva, Aleksandra A.,Zhdankin, Viktor V.
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supporting information; experimental part
p. 11091 - 11094
(2010/04/28)
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- A facile mild deprotection protocol for 1,3-dithianes and 1,3-dithiolanes with 30% hydrogen peroxide and iodine catalyst in aqueous micellar system
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A simple clean expeditious protocol for the deprotection of 1,3-dithianes and 1,3-dithiolanes has been developed using 30% aqueous hydrogen peroxide activated by iodine catalyst (5 mol%) in water in the presence of sodium dodecyl sulfate (SDS) under essentially neutral conditions. The method showed tolerance for a number of phenol protecting groups such as allyl, benzyl, TBDMS, TBDPS ethers, phenolic acetates, and benzoates as well as amino-protecting BOC, Cbz carbamates without any detectable overoxidation. Georg Thieme Verlag Stuttgart.
- Ganguly, Nemai C.,Barik, Sujoy Kumar
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experimental part
p. 1393 - 1399
(2009/12/29)
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- Copper(II) chloride dihydrate: A catalytic agent for the deprotection of tetrahydropyranyl ethers (THP ethers) and 1-ethoxyethyl ethers (EE ethers)
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Tetrahydropyranyl ethers (THP groups) and 1-ethoxyethyl ethers (EE groups) are removed upon refluxing in 95% EtOH or Me2CO-H2O (95:5) in the presence of a catalytic amount of copper(II) chloride dihydrate (2-5 mol%).
- Wang, Jianbo,Zhang, Chao,Qu, Zhaohui,Hou, Yihua,Chen, Bei,Wu, Peng
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p. 294 - 295
(2007/10/03)
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- Thermochemical Studies of Carbonyl Reactions. 4. Enthalpies of Hydrolysis of Norbornyl Ketals
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The dimethyl ketals of norbornanone and of eight methyl-substituted norbornanones were prepared, and the enthalpies of hydrolysis were determined.The compounds were chosen to provide a variety of steric interactions between the methyl substituents and the ketal group, much of which would be relieved on going to the ketone.The enthalpies of reaction varied by over 4 kcal/mol.The experimental data were modeled by molecular mechanics (MM2), and although a good correlation was found for the less substituted compounds, the ketal of camphor fell off the slope = 1 correlation line.The free energy changes were determined, and were found not to be well correlated with the enthalpy changes.
- Wiberg, Kenneth B.,Cunningham, Wells C.
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p. 679 - 684
(2007/10/02)
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- Barium Ferrate Monohydrate BaFeO4.H2O, a Useful Oxidant for the Oxidation of Organic Compounds under Aprotic Conditions
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Preparation of barium ferrate monohydrate with a slight modification is described.It is shown that this reagent is capable of oxidizing different organic compounds and could be used as a versatile reagent in organic synthesis.Primary and secondary alcohols are converted to their carbonyl compounds, α-hydroxy ketones to their diketones, and hydroquinones to their quinones.Aromatic amines are converted to their azo compounds, benzylamine to benzaldehyde, phenylhydrazones and oximes to their carbonyl compounds.Thiols are also converted to their disulfides in high yields.This reagent seems to be a non-toxic and a non-pollutant compound.
- Firouzabadi, Habib,Mohajer, Daryoush,Entezari-Moghadam, Mohsen
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p. 2185 - 2190
(2007/10/02)
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- 13C MAGNETIC RESONANCE STUDIES. 129. HOMOENOLIZATION IN THE CAMPHENILONE SYSTEM. EXAMINATION OF SOME 7-SUBSTITUTED DERIVATIVES
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The behavior of the 7,7-dimethyl, 7-spirocyclopropyl, and 7-isopropylidene derivatives of champhenilone under strongly basic conditions (t-BuO-/t-BuOH/185 deg C) has been investigated to examine substituent effects on β-enolization in the system.In each case, an equilibrium mixture of the initial ketone and its corresponding 5-substituted isomer was obtained, with the latter increasingly favored through the series.In each case the 1H/2H exchange processes were examined by experiments utilizing t-BuO-/t-BuOD to establish the individual sites of deuterium incorporation in these ketones with 2H and 13C magnetic resonance.These data provide the stereoselectivities and relative rates of the exchange processes.The 2H-induced effects in the 13C spectra are discussed.
- Peiris, Sriyawathie,Ragauskas, Arthur J.,Stothers, J. B.
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p. 789 - 797
(2007/10/02)
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- BARIUM FERRATE NONOHYDRATE BaFeO4, H2O, A VERSATILE REAGENT FOR THE OXIDATION OF ORGANIC COMPOUNDS UNDER APROTIC CONDITION
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Barium ferrate monohydrate which seems to be a safe and a non-pollutant compound, is an easily prepared, a quite stable and a cheap oxidant.Its uses as a versatile oxidizing agent of organic compounds are described.
- Firouzabadi, H.,Mohajer, D.,Entezari-Moghaddam, M.
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p. 723 - 732
(2007/10/02)
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- MODEL STUDIES IN THE TAXANE DITERPENE SERIES - Part. I
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Photochemical cycloaddition of enol acetate 10a to cyclohexene led to a 3:1 mixture of the tetracyclic photoadducts A and B which, trough reverse aldol reactions, under mild alkaline conditions produced two compounds: a tetracyclic ketone 13 and a tricyclic diketone 14.Hydrolytic cleavage in methanolic hydrochloric acid of 15 and 16 resulting from irradiation of the enol ether 10b to cyclohexene gave rise to the rearranged tricyclic diketone 14 only.The trans stereochemistry 3α, 8β of the fused-ring system in 14, established by X-ray measurements, is different from the stereochemistry of the naturally occuring taxane derivatives.Ejus elementi compositionem quod vim habet in taxo baccata, photochimiae beneficio, quidam in exemplo simpliciore reddito experti sunt.Perincommode tamen accidit ut materiae ita quaesitae figura dissimilis sit ejus rei natura praebitae.
- Cervantes, Humberto,Khac, Duc Do,Fetizon, Marcel,Guir, Frederic,Beloeil, Jean-Claude,Lallemand, Jean-Yves
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p. 3491 - 3502
(2007/10/02)
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- BARIUM MANGANATE. A VERSATILE OXIDANT IN ORGANIC SYNTHESIS.
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Preparation of barium manganate in large-scale is discussed. It is also shown that this reagent is capable of oxidizing organic substrates, converting alcohols to their corresponding carbonyl compounds, aromatic amines to their corresponding azo compounds, hydroquinone to p-benzoquinone, benzylamine to benzaldehyde, and triphenylphosphine to its oxide in good yields. Saturated hydrocarbons, unsaturated hydrocarbons, unsaturated ketones, and saturated amines are not affected by this reagent in a reasonable reaction time.
- Firouzabadi,Mostafavipoor
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p. 914 - 917
(2007/10/02)
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