Dihydrobenzopyran, thiochroman, tetrahydroquinoleine and tetrahydronaphthalene derivatives and their use in anti-cancer therapy
New dihydrobenzopyran, thiochroman, tetrahydroquinoleine and tetrahydronaphthalene derivatives and their use in anti-cancer therapy with the general formula :
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(2012/08/28)
Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors
A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities.
Lee, Jinho,Kim, Kyoung-Hee,Jeong, Shinwu
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p. 4203 - 4205
(2011/08/06)
3-benzylaminopiperidines as tachykinin receptor antagonists
PCT No. PCT/GB96/02998 Sec. 371 Date Jun. 9, 1998 Sec. 102(e) Date Jun. 9, 1998 PCT Filed Dec. 6, 1996 PCT Pub. No. WO97/21702 PCT Pub. Date Jun. 19, 1997The present invention relates to certain 3-benzylaminopiperidines which are tachykinin receptor antag
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(2008/06/13)
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