- Method for preparing alkyl diether compound
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The invention relates to the field of synthesis of alkyl diether compounds, and provides a method for preparing an alkyl diether compound with the structure shown as the formula (I). The method comprises the steps that in the presence of concentrated sulfuric acid, an ethanediol compound with the structure shown as the formula (II) and olefin C1-C8 are subjected to a haptoreaction. The alkyl diether compound prepared through the preparation method is high in purity, low in impurity content and simple in preparation process, concentrated sulfuric acid is adopted as a catalyst to replace a traditional sodium alkoxide synthesis method, and high safety and high universality are achieved. The formulas are shown in the specification, wherein R1 and R2 independently serve as alkyl groups of C1-C8, and R1 and R2 do not serve as the alkyl groups at the same time, and R'1 is hydrogen or alkyl groups of C1-C8.
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Paragraph 0044-0046
(2017/08/30)
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- Deamination Reactions, 41. Reactions of Aliphatic Diazonium Ions and Carbocations with Ethers
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Aliphatic diazonium ions and carbocations were generated by deacylation of appropriate nitrosoureas (1, 5, 9) in alcohol-ether mixtures or in 2-alkoxyethanols.Ethers were generally inferior to alcohols in capturing cationic intermediates.Formation of trialkyloxonium ions led to alkyl exchange or ring opening.The observed reactivity orders were n-butyl > isobutyl for the diazonium ions, allyl > sec-butyl > tert-butyl for the carbocations, methoxy > ethoxy and oxirane > oxetane > tetrahydrofuran for the ethers, indicating the predominance of steric effects.Neighboring group participation in 4-methoxy-1-butanediazonium ions (58) and 4,5-epoxy-1-pentanediazonium ions (74) was detectable but inefficient ( 20percent of cyclic oxonium ions).
- Kirmse, Wolfgang,Jansen, Ulrich
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p. 2607 - 2625
(2007/10/02)
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