- Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof
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Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (?)-ambroxide.
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Page/Page column 83
(2016/06/28)
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- A short and efficient synthesis of (+)-totarol
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A concise route to multigram quantities of the antibacterial diterpene (+)-totarol (1) is reported. (-)-Sclareol (2) was converted to the target compound 1 using either a six- or a seven-step sequence, while only three steps were required to access (+)-totarol ( 1) starting from (+)-manool (9) or (+)-13-epi-manool (10), respectively. A novel one-pot intramolecular aldol condensation/α-alkylation protocol served as the key operation for streamlining the syntheses of 1. ARKAT-USA, Inc.
- Rogachev, Victor,Loehl, Thorsten,Markert, Thomas,Metz, Peter
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p. 172 - 180
(2013/09/24)
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- A SHORT SYNTHESIS OF AMBROX FROM SCLAREOL
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A two-step transformation of sclareol into Ambrox (overall yield 11-12percent) via β-cleavage of an alkoxy radical intermediate is described.
- Decorzant, Rene,Vial, Christian,Naf, Ferdinand,Whitesides, George M.
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p. 1871 - 1880
(2007/10/02)
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- STRUCTURE OF NEW BROMODITERPENES, PINNATOLS, FROM THE MARINE RED ALGA LAURENCIA PINNATA YAMADA
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The structure of new bromoditerpenes named pinnatols A, B, C, and D, isolated from the title alga, was determined on the basis of the chemical and spectral data.
- Fukuzawa, Akio,Miyamoto, Mitsuaki,Kumagai, Yoshikazu,Abiko, Atsushi,Takaya, Yoshiaki,Masamune, Tadashi
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p. 1259 - 1262
(2007/10/02)
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