- Synthesis of N-[2-benzyloxy-5-(2-oxiranyl)-phenyl]formamide: Formal synthesis of formoterol
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Nitration, benzylation followed by bromination of 4- hydroxyacetophenone is described to obtain nitrobenzyloxyphenacyl bromide derivative 3. Sodiumborohydride reduction of 3 gives rise to the diol 6. Reaction of 6 with Ph3P/I2/imidaz
- Mereyala, Hari Babu,Sambaru, Kalyani
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p. 167 - 169
(2007/10/03)
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- 2-(3-Benzyloxy-4-nitrophenyl)oxirane, an Intermediate in the Synthesis of Formoterol
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In the title compound, C15H13NO4, the two planar nitrophenyl and benzyloxy groups are inclined at 152.3(2) deg.The torsion angle about the central C-O bond is 177.5(5) deg, giving an extended C-C-O-C chain.The nitro group is twisted out of the plane of the phenyl ring by 28.4(3) deg to diminish steric hindrance; O atoms of the nitro and benzyloxy groups are separated by only 2.625(7) Angstroem.The dihedral angles between the epoxy ring and the two aromatic rings are 98.3(3) and 102.6(3) deg.There is a possible C-H...O intermolecular interaction.
- Mohan, K. Chandra,Ravikumar, K.,Vittal, T. V. S. K.,Gido, C. K.
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p. 1294 - 1295
(2007/10/02)
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- Bronchospasmolytic phenylethanolamines
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Phenylethanolamines of the formula I STR1 wherein R is substituted phenyl or optionally substituted furyl, thienyl, or pyridyl, R5 is hydrogen, lower alkyl, or optionally substituted benzyl, R4, R6, R8, and Rsu
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