- A Synthesis of an Alkylated Taxane Model System
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A new synthesis of the model compound 8,12,15,15-tetramethyltricyclo3,8>pentadecane using LiCMe2SePh in a method to produce highly substituted dienes is reported.
- Bonnert, Roger V.,Jenkins, Paul R.
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p. 413 - 418
(2007/10/02)
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- A New Synthesis of Substituted Dienes and its Application to an Alkylated Taxane Model System
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A new synthesis of highly substituted dienes using LiCMe2SePh is reported, along with its application to the synthesis of the taxane model compound 8,12,15,15-tetramethyltricyclo3,8>pentadecane
- Bonnert, Roger V.,Jenkins, Paul R.
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p. 1540 - 1541
(2007/10/02)
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- SYNTHESIS AND APPLICATION OF α-METHOXYALLYL SULFIDES AS A NOVEL α-METHYLENATED ACYL ANION EQUIVALENT
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α-methoxyallyl sulfides prepared from methoxy(phenylthio)methane proved to be a novel acyl anion equivalent providing a new synthetic method for α-methylenated ketones.
- Mandai, Tadakatsu,Takeshita, Masahiro,Kawada, Mikio,Otera, Junzo
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p. 1259 - 1260
(2007/10/02)
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- A NEW SYNTHESIS OF α-METHYLENE CARBONYL COMPOUNDS
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α-Methylene carbonyl compounds are regioselectively prepared by the reaction of α-nitroketones or α-nitroesters with 37percent formaldehyde in the presence of a catalytic amount of weak bases followed by acetylation, denitration with Bu3SnH, and elimination of acetic acid.
- Ono, Noboru,Miyake, Hideyoshi,Fujii, Masayuki,Kaji, Aritsune
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p. 3477 - 3480
(2007/10/02)
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- INSERTION D'ALLENES. VIII. FORMATION DE CETONES α,β-INSATUREES PAR HYDROACYLATION D'ALLENES EN PRESENCE DE TETRACARBONYL FERRATE DE SODIUM
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α,β-Unsaturated ketones are generated in moderate yields (50-60percent) from allene or a mono-, di- or tri-substituted allenic hydrocarbon, an alkyl halide and sodium tetracarbonylferrate.The first step is the formation of a complex anion which results from transfer of the alkyl group on a coordinated CO, then of the acyl ligand thus formed on the allenic sp carbon.Protonation with acetic acid yields a hydroxy-η4-trimethylenemethane, easily isomerised into an η4-heterodieneiron tricarbonyl.Finally, the α,β-unsaturated ketone is released upon oxidation with trimethylamine oxide.The most substituted ketone predominates.
- Roustan, J. L.,Guinot, A.,Cadiot, P.
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p. 367 - 378
(2007/10/02)
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