Inhibition of chitin synthases and antifungal activities by 2′-benzoyloxycinnamaldehyde from Pleuropterus ciliinervis and its derivatives
In the course of search for potent chitin synthase inhibitors from natural resources, a novel chitin synthases inhibitor, 2′-benzoyloxycinnamaldehyde (2′-BCA) (I), was isolated from the aerial parts of Pleuropterus ciliinervis NAKAI. 2′-BCA inhibited chit
Kang, Tae Hoon,Hwang, Eui Il,Yun, Bong Sik,Park, Ki Duk,Kwon, Byoung Mog,Shin, Chul Soo,Kim, Sung Uk
p. 598 - 602
(2008/02/02)
The constituents and synthesis of cryptamygin-A from the stem bark of Cryptocarya amygadalina
Three new benzenoid compounds, namely cryptamygin-A, -B and -C together with eleven known compounds were isolated from the stem bark of Cryptocarya amygadalina. Their structures were elucidated by spectral analysis. The synthesis of cryptamygin-A is also
A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.
Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors
A series of 2-hydroxycinnamaldehyde derivatives was synthesized for examing a structure-activity relationship for inhibition of angiogenesis. The anti-angiogenic effects of 2'-substituted cinnamaldehydes and related analogs were determined in a chick embryo chorioallantoic membrane assay system.