- Synthetic method of 2-aminomalononitrile
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The invention discloses a synthetic method of 2-aminomalononitrile. The synthetic method comprises the following steps of: 1) adopting aminomalonic acid diethyl ester as a starting material, directlyplacing into 40-60w/v% of ammonium-chloride aqueous solution, reacting for 2-5 hours at a temperature of 100-120 DEG C and preparing to obtain 2-aminopropanediamide; 2) dissolving 2-aminopropanediamide prepared in the step 1) into an organic solvent, heating to rise the temperature, adding solid phosgene, heating and refluxing for 10-12 hours to generate 2-aminomalononitrile. The synthetic methoddisclosed by the invention is simple, pollution-free, safe and environmentally friendly and provides basis for further application of 2-aminomalononitrile.
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Paragraph 0020; 0021; 0022; 0023
(2018/07/30)
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- Process for the production of aminomalonic acid dinitrile as an aminomalonic acid dinitriltosylate precipitate or as an acetylaminomalodinitrile precipitate
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Process for the production of aminomalonic acid dinitrile from a malonic acid dinitrile compound, such as oximinomalonic acid dinitrile or phenylazomalonic acid dinitrile. The reaction is carried out at an elevated hydrogen pressure in the presence of Raney catalysts and a solvent. When tetrahydrofurane is used as a solvent, the reaction product is precipitated with p-toluene sulfonic acid. When acetic anhydride is used as solvent, the reaction product is precipitated as acetyl aminomalonic acid dinitrile.
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- Purines, Pyrimidines, and Imidazoles. Part 56. Some Aminoimidazolecarboxamidines and Derived Adenines
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5-Amino-4-cyano-1-cyclohexylimidazole, prepared from aminomalononitrile, triethyl orthoformate, and cyclohexylamine with methanolic hydrogen chloride, produced methyl 5-amino-1-cyclohexylimidazole-4-carboximidate, which with ammonia gave 5-amino-1-cyclohe
- Kadir, Kamaliah,Shaw, Gordon,Wright, David
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p. 2728 - 2731
(2007/10/02)
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