Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma
We identified a new benzothiophene containing Rho kinase inhibitor scaffold in an ultra high-throughput enzymatic activity screen. SAR studies, driven by a novel label-free cellular impedance assay, were used to derive 39, which substantially reduced intr
Davis, Robert L.,Kahraman, Mehmet,Prins, Thomas J.,Beaver, Yan,Cook, Travis G.,Cramp, Jessica,Cayanan, Charmagne S.,Gardiner, Elisabeth M.M.,McLaughlin, Marsha A.,Clark, Abbot F.,Hellberg, Mark R.,Shiau, Andrew K.,Noble, Stewart A.,Borchardt, Allen J.
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p. 3361 - 3366
(2010/08/07)
BENZOTHIOPHENE INHIBITORS OF RHO KINASE
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Page/Page column 16; 24
(2008/06/13)
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