- Synthesis method of tocopherol nicotinate
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The invention belongs to the technical field of organic chemical synthesis, and relates to a method for preparing tocopherol nicotinate from 3-pyridylaldehyde and tocopherol. According to the method, 3-pyridylaldehyde and tocopherol are used as raw materials, N-heterocyclic carbene is used as a catalyst, and tocopherol nicotinate is synthesized through oxidative esterification. The method has the advantages of cheap raw materials, mild reaction conditions, simple process, greenness, safety, high efficiency and environmental protection, and is suitable for industrial production.
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Paragraph 0008; 0016; 0018-0033
(2021/10/30)
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- Highly selective trifluoromethylation of 1,3-disubstituted arenes through iridium-catalyzed arene borylation
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The old one two: A sequential iridium-catalyzed borylation and copper-catalyzed trifluoromethylation of arenes is described (see scheme; Pin=pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. T
- Liu, Tianfei,Shao, Xinxin,Wu, Yaming,Shen, Qilong
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supporting information; experimental part
p. 540 - 543
(2012/03/11)
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- One-pot preparation of esters from carboxylic acids using the PPh3-CCl3CN system
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A convenient one-pot process for preparing various esters from carboxylic acids using the Ph3P-CCl3CN has been developed. Racemic α-tocopherol, clofibrate and flavoxate were prepared in high yields using this method.
- Jang, Doo Ok,Cho, Dae Hyan,Kim, Joong-Gon
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p. 2885 - 2890
(2007/10/03)
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- Cosmetic composition
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Compositions containing an ester of nicotinic acid and a cosmetically acceptable surfactant are provided. These compositions, when applied topically to the human body produce a response such as a sensory or therapeutic response, for example a tingling or warming sensation or an increase in blood flow, which persists after the composition is rinsed from the body. The compositions are particularly suitable for application to the hair and/or scalp where they may encourage hair growth. Compositions for application to the hair and/or scalp preferably additionally comprise hair benefit agents such as hair growth promoters.
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