- Method for preparing matrine from oxymatrine by metal reducing agent
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The invention relates to a method for preparing matrine from oxymatrine by a metal reducing agent. The method includes the steps of dissolving 65%-100% oxymatrine into a 50%-100% water-containing strong polar solvent, adding the metal reducing agent and electrolyte into the obtained mixed solution to react for 0.5-8 hours at 40 DEG C-100 DEG C, concentrating the reacted solution to 50 DEG C under reduced pressure to obtain the relative density of 1.02-1.06 through thermal test, using a water-insoluble organic solvent 2.0-4.5 in polarity to extract the concentrated solution, and subjecting the extracted solution to evaporation prior to crystallization, centrifugal separation and drying so as to obtain white crystal matrine. The method for preparing the matrine from the oxymatrine by the metal reducing agent has the advantages that the method is simple and convenient to operate, low in preparation cost and easy to industrialize; conversion yield and product purity exceed 96% and 98% respectively; enterprises producing the matrine and the oxymatrine can convert the matrine and the oxymatrine flexibly so as to adapt to changed demand of the market on the matrine and the oxymatrine.
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Paragraph 0024; 0025; 0026
(2017/08/29)
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- B(C6F5)3-Catalyzed Deoxygenation of Sulfoxides and Amine N-Oxides with Hydrosilanes
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An efficient strategy for the deoxygenation of sulfoxides and amine N-oxides by using B(C6F5)3 and hydrosilanes was developed. This method provided the corresponding aromatic and aliphatic products in good to high yields and showed good functional-group tolerance under mild conditions.
- Ding, Fangwei,Jiang, Yanqiu,Gan, Shaoyan,Bao, Robert Li-Yuan,Lin, Kaifeng,Shi, Lei
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p. 3427 - 3430
(2017/07/04)
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- Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents
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A series of furoxan-based nitric oxide-releasing matrine derivatives (10a-f) were synthesized. The biological evaluation showed that compounds 10a, 10b, 10e and 10f had stronger cytotoxic activities than 5-fluorouracil against human hepatoma cells (HepG2) in vitro.
- He, Li Qin,Liu, Jing,Yin, Deng Ke,Zhang, Yi Hua,Wang, Xiao Shan
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scheme or table
p. 381 - 384
(2010/12/25)
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- PROCESS FOR THE PURIFICATION OF SOPHORA ALKALOIDS
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A method of purifying alkaloids extracted from plants of the Sophora genus (Sophora alkaloids), characterised in that the method comprises a purification step in which the Sophora alkaloids are placed on a macroporous absorption resin with an eluent comprising at least 40wt% water.
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Page/Page column 9-10
(2009/10/22)
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