- Two Colour Photoflow Chemistry for Macromolecular Design
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We report a photochemical flow setup that exploits λ-orthogonal reactions using two different colours of light (λ1=350 nm and λ2=410 nm) in sequential on-line irradiation steps. Critically, both photochemically reactive units (a visi
- Barner-Kowollik, Christopher,Blinco, James P.,De Bruycker, Kevin,Van De Walle, Matthias
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supporting information
p. 14143 - 14147
(2020/06/10)
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- OXIME COMPOUND AND HERBICIDE
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PROBLEM TO BE SOLVED: To provide a novel agrochemical, particularly a herbicide. SOLUTION: The present invention provides an oxime compound represented by formula (1) [where B is B-1 or the like, Q is NOR7, A is a hydrogen atom, C1-C6 alkyl or the like, R6 is a halogen atom, -N(R6c) R6d or the like, R6c and R6d are hydrogen atoms, R7 is a hydrogen atom, C1-C6 alkyl or the like, R10, R11 and R12 are hydrogen atoms, Z is C1-C6 alkyl or the like, q is an integer of 0-5] and a herbicide containing the same. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
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Paragraph 0240
(2019/07/31)
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- Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C-H Methoxylation and Chlorination of Benzaldehydes
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We report Pd-catalyzed ortho-C-H methoxylation and chlorination of benzaldehydes by employing monodentate transient directing groups (TDGs) as an alternative strategy to bidentate TDGs. More importantly, a single crystal of benzaldehyde imine ortho-cyclopalladium intermediate was successfully obtained, and its structure was unambiguously determined by X-ray diffraction, which clearly showed that it was a binuclear palladium species bridged by a pyridone ligand. The utility of this approach was further demonstrated through the synthesis of key intermediates of natural products and drugs.
- Li, Feng,Zhou, Yirong,Yang, Heng,Wang, Ziqi,Yu, Qinqin,Zhang, Fang-Lin
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supporting information
p. 3692 - 3695
(2019/05/24)
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- Synthesis of oxygenated orthomethylbenzaldehydes via aryne [2+2] cycloaddition and benzocyclobutenol ring opening
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Herein, a two-step procedure for the preparation of oxygenated ortho-methylbenzaldehyde derivatives, starting from commercially available bromoarenes, is described. The synthesis features the simultaneous and highly regioselective installation of both the methyl and the formyl group onto the benzene core via benzyne [2+2] cycloadditions with acetaldehyde lithium enolate to give the corresponding benzocyclobutenols in high yields. Bond-selective ring opening of the benzocyclobutenols under basic conditions in methanol delivers the title compounds.
- Maturi, Mark M.,Ohmori, Ken,Suzuki, Keisuke
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p. 870 - 873
(2019/01/21)
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- 2-BENZYL-BENZIMIDAZOLE COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF
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The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical comp
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Page/Page column 47
(2015/05/19)
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- Formylation of electron-rich aromatic rings mediated by dichloromethyl methyl ether and TiCl4: Scope and limitations
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Here the aromatic formylation mediated by TiCl4 and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. Here we determine that the regioselectivity of this process is highly promoted by the coordination between the atoms present in the aromatic moiety and those in the metal core.
- Ramos-Tomillero, Iván,Paradís-Bas, Marta,De Pinho Ribeiro Moreira, Ibério,Bofill, Josep María,Nicolás, Ernesto,Albericio, Fernando
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supporting information
p. 5409 - 5422
(2015/05/13)
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- A direct and mild formylation method for substituted benzenes utilizing dichloromethyl methyl ether-silver trifluoromethanesulfonate
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A silver trifluoromethanesulfonate (AgOTf)-promoted direct and mild formylation of benzenes has been developed. The reaction utilizing dichloromethyl methyl ether (Cl2CHOMe) and AgOTf powerfully formylated various substituted benzenes under temperature conditions as low as -78 C without losing the protecting groups on the phenolic hydroxyl group.
- Ohsawa, Kosuke,Yoshida, Masahito,Doi, Takayuki
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p. 3438 - 3444
(2013/06/26)
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- Phenyl-substituted Bicyclooctane-1,3-dione Derivatives
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The invention relates to novel compounds of the formula (I) in which X, Y, Z, A, B and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides. Moreover, the inv
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Page/Page column 63
(2011/04/13)
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- Studies on oxidations with IBX: Oxidation of alcohols and aldehydes under solvent-free conditions
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A variety of allylic and benzylic alcohols are oxidized to their respective carbonyl compounds with IBX under solvent-free conditions at ca. 60-70°C. It has also been found that some of the aromatic aldehydes also undergo oxidation when heated with IBX at 90°C under solvent-free conditions; notably, this transformation does not occur under the otherwise identical but heterogeneous conditions.
- Moorthy, Jarugu Narasimha,Singhal, Nidhi,Venkatakrishnan
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p. 5419 - 5424
(2007/10/03)
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- De novo design, synthesis, and evaluation of novel nonsteroidal phenanthrene ligands for the estrogen receptor
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Although there are many estrogen receptor antagonists with improved tissue selectivity profiles compared with tamoxifen, optimal tissue selectivity has not yet been demonstrated. As such there is still a need for additional diversity and new chemical scaf
- Schmidt, Jonathan M.,Mercure, Julie,Tremblay, Gilles B.,Pagé, Martine,Kalbakji, Aida,Feher, Miklos,Dunn-Dufault, Robert,Peter, Markus G.,Redden, Peter R.
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p. 1408 - 1418
(2007/10/03)
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- Ring-chain tautomerism, oxidation, and NO-reaction of a sterically hindered 1,3-dihydroxyimidazolidine
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The bis-hydroxylamine 1 does not react with the hindered benzaldehyde 2 in ethanolic solution, in DMSO or DMF even at high temperatures. Reaction only takes place after melting the components without any solvent at about 150°C. The product shows ring-chai
- Weber,Grzesiok
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p. 823 - 827
(2007/10/03)
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- Direct synthesis of G-2N
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The synthesis of angularly fused quinone natural products has been achieved using a photoenolization reaction and a Diels-Alder reaction in the key carbon-carbon bond forming steps.
- Kraus, George A.,Zhao, Guohua
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p. 2770 - 2773
(2007/10/03)
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- Process for formylation of aromatic compounds
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A process for the preparation of a formylated aromatic compound comprising contacting an aromatic compound with (i) a halogenated compound in the presence of a Lewis acid, and (ii) a base, is described. The subject process provides an efficient and effect
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