- NOVEL XYLENE-BASED AMPHIPHILIC COMPOUND AND USE THEREOF
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The present invention relates to a xylene-based amphiphilic compound, a method for preparing the same, and a method for extracting, solubilizing, stabilizing or crystallizing a membrane protein using the same. By using the xylene-based compound according to the present invention, a membrane protein may be stably stored in an aqueous solution for a long time, and may be applied in functional and structural analyses. The structural and functional analysis of the membrane protein is one of the fields of highest interest in biology and chemistry, and the xylene-based compound according to the present invention can be applied in research on protein structure that is closely related to development of a new drug.
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Paragraph 0168; 0178; 0179; 0188; 0193
(2018/10/19)
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- Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation
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Membrane proteins are key functional players in biological systems. These biomacromolecules contain both hydrophilic and hydrophobic regions and thus amphipathic molecules are necessary to extract membrane proteins from their native lipid environments and
- Cho, Kyung Ho,Du, Yang,Scull, Nicola J.,Hariharan, Parameswaran,Gotfryd, Kamil,Loland, Claus J.,Guan, Lan,Byrne, Bernadette,Kobilka, Brian K.,Chae, Pil Seok
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supporting information
p. 10008 - 10013
(2015/07/07)
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- The synthesis and electro-optic properties of liquid crystalline 2- (2,3-difluorobiphenyl-4'-yl)-1,3-dioxanes
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Fifty-six novel alkyl and/or alkoxy disubstituted 2-(2,3- difluorobiphenyl-4'-yl)-1,3-dioxanes (DFBPD) were prepared. Smectic C and nematic mesophases were exhibited by most of the alkyl-alkoxy homologues. Conversely, most of the dialkyl compounds exhibited smectic C, smectic A and nematic phases. The birefringence (Δn), dielectric anisotropy (Δε), spontaneous polarisation and response times of two ferroelectric mixtures formulated from the dioxanyl systems were determined. The birefringence results were compared with eight other groups of mixtures where the materials were based on different core systems. The overall electro-optic properties of the DFBPDs were found to be comparable to the best of the eight most commonly used materials in ferroelectric display devices.
- Dong, Chu Chuan,Styring, Peter,Goodby, John W.,Chan, Lawrence K. M.
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p. 1669 - 1677
(2007/10/03)
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- TITANIUM CATALYST, ORGANOTITANIUM REACTION REAGENT, PROCESSES FOR PRODUCING THESE, AND METHOD OF REACTION USING THESE
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A titanium catalyst for reaction between a carbon-carbon unsaturated bond and a compound having an electrophilic functional group or an electrophilic reagent, said titanium catalyst being composed of a titanium compound represented by the formula (1) below TiX1X2X3X4(where X1, X2, X3, and X4denote independently a halogen atom, C1-20alkoxyl group, aralkyloxy group, aryloxy group, or -NRxRy group (where Rx and Ry denote independently a C1-20alkyl group or aralkyl group), and any two of X1, X2, X3, and X4may form a ring.) and a Grignard reagent represented by the formula (2) below in a molar amount 1.5-2.5 times as much as the titanium compound. R1MgX5(where R1denotes a C2-10alkyl group having a hydrogen atom at the β position and X5denotes a halogen atom.) The titanium catalyst of the present invention activates the carbon-carbon unsaturated bond, which has a comparatively low reactivity, thereby catalyzing the reaction with an electrophilic functional group. It is inexpensive and industrially advantageous. When applied to reaction between a carbon-carbon unsaturated bond and an electrophilic functional group, it yields industrially a variety of adducts of a compound having a carbon-carbon unsaturated bond and a compound having an electrophilic functional group, and it also yields a variety of intramolecular adducts of a compound having a carbon-carbon unsaturated bond and an electrophilic functional group in the same molecule.
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- SYNTHESIS OF NEW LIPOPHILIC LIGANDS AND NMR MEASUREMENT OF THEIR CRITICAL MICELLAR CONCENTRATION (CMC)
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New lipophilic ligands are synthesized to build potential Magnetic Resonance Imaging contrast agents (MRI).Using the evolution of 1H-NMR chemical shifts δ with concentration of monomer in D2O, the critical micellar concentration (CMC) has been measured. - Key words: Contrast agents; M.R.I.; C.M.C.; micelles.
- Nguyen, M. V. D.,Brik, M. E.,Ouvrard, B. N.,Courtieu, J.,Nicolas, L.,Gaudemer, A.
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p. 181 - 184
(2007/10/03)
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- Ring opening of cyclopropanemonocarboxylates and 1,1- cyclopropanedicarboxylates using samarium(II) diiodide (SmI2)-HMPA-THF system
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The cyclopropane ring in 2-substituted 1,1-cyclopropanedicarboxylates was regioselectively opened by using samarium(II) diiodide (Sml2) in a hexamethylphosphoric triamide (HMPA)-tetrahydrofuran (THF) (1:10) system under mild and neutral conditions to give (2-substituted ethyl)malonates in moderate to good yields. The cyclopropane ring in 2-substituted cyclopropanecarboxylates or 2-substituted 3- (trimethylsilyl)cyclopropanecarboxylates was similarly cleaved regioselectively by using Sml2 in a HMPA-THF (1:1) system to give 4- arylbutyrates or 4-aryl-3-(trimethylsilyl)butyrates in 16-89% yields. The reaction mechanism of these ring-opening reactions is discussed.
- Yamashita,Okuyama,Ohhara,Kawasaki,Sakai,Nakata,Kawabe,Kusumoto,Ohta
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p. 2075 - 2081
(2007/10/03)
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- Synthesis of Dinitroxides of Potential Use as Contrast Agent in MRI
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Dinitroxides derived from 6-alkyl-1,4,8,11-tetraazaundecane-5,7-dione have been synthesized in three steps.These compounds, which contain two paramagnetic centers, are more effective proton relaxation agents than those containing only one nitroxyl moiety and could be used in smaller quantities as contrast agents in MRI.
- Brik, Mohab-Eddine,Nguyen, Marguerite Van Duong,Nicolas, Louisette,Courtieu, Jacques,Gaudemer, Alain
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p. 2183 - 2190
(2007/10/02)
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- Synthesis of 3-Heptyl- and 3-Nonyl-2,4(1H,3H)-quinolinediones
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3-Alkyl-3-hydroxy-2,4(1H,3H)-quinolinediones 4, which are metabolites of some Pseudomonas species, were synthesized by oxidation of the corresponding 4-hydroxy-2(1H)-quinolones 3.By halogenation of 3 the 3-chloro- and 3-bromo-2,4(1H,3H)-quinolinediones 5 and 7, respectively, are obtained.Exchange of the chloro substituent in 5 with sodium azide yields the 3-azido derivative 8, while reaction with potassium fluoride affords the 3-fluoroquinolinedione 6.
- Laschober, Rita,Stadlbauer, Wolfgang
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p. 1083 - 1086
(2007/10/02)
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