- Investigation of the sunscreen octocrylene's interaction with amino acid analogs in the presence of UV radiation
-
Octocrylene is an organic UV filter, commonly used in sunscreens and cosmetics, which can give rise to both contact and photocontact allergy. Our aim was to investigate octocrylene's interaction with amino acid analogs in the presence of UV radiation to b
- Karlsson, Isabella,Persson, Elin,M?rtensson, Jerker,B?rje, Anna
-
-
Read Online
- Preparation method of sun-screening agent intermediate etocrilene
-
The invention provides a preparation method of etocrilene. The method uses benzophenone imine and ethyl cyanoacetate as raw materials, wherein benzophenone imine is prepared through benzophenone and ammonia. The method has the advantages of mild reaction conditions, high purity of the prepared etocrilene product, high yield of the process method, less three wastes, simple operation and easy control. Industrialized production can be achieved easily.
- -
-
Paragraph 0087-0087
(2021/02/06)
-
- Preparation method of cyanoacrylate ultraviolet light absorber
-
The invention provides a preparation method of a cyanoacrylate ultraviolet light absorber. Benzophenone compounds represented by general formula I with cyanoacetate under a weakly alkaline condition by using activated carbon grafted acidic ionic liquid as a catalyst to generate a compound represented by general formula II. The preparation method of the cyanoacrylate ultraviolet light absorber adopts the activated carbon grafted acidic ionic liquid catalyst to replace acetic acid, so that the preparation method has the advantages of easiness in recycling of the catalyst, high product yield, fewthree wastes, and convenience in post-treatment, and is an economical, practical and environment-friendly technology.
- -
-
Paragraph 0093-0094; 0099-0104
(2020/04/29)
-
- Preparation method of Etocrilene
-
The invention discloses a preparation method of Etocrilene. The method comprises the following steps: 1), benzophenone, ethyl cyanoacetate, ammonium acetate and acetic acid are added into a reaction container in proportion, and then are heated and dissolved; 2), vacuumizing is performed gradually to reach a preset vacuum degree, the temperature is raised to a first preset temperature, and then iskept, a preset amount of acetic anhydride is added into the reaction container, and a reaction is carried out for 8-12 h; and 3), the container is cooled to a second preset temperature, the obtained reaction product is washed with water, stands and stratifies, and the obtained upper oil layer is taken, cooled for crystallization, filtered and dried to obtain the target product Etocrilene. The prepared Etocrilene has a high purity and few impurities; and the acetic anhydride is added in the preparation process, and a two-catalyst mode combining 1,3-dialkylimidazolium oxometallate and acetic acid is adopted to replace a traditional single-catalyst mode, so the conversion rate is greatly improved.
- -
-
Paragraph 0028-0041
(2019/09/13)
-
- Synthesis of coumarins via PIDA/I2-mediated oxidative cyclization of substituted phenylacrylic acids
-
A variety of functionalized coumarins were synthesized from substituted phenylacrylic acids via PIDA/I2-mediated and irradiation-promoted oxidative carbon-oxygen bond formation. Our studies show that the oxygen in the pendant carboxylic acid group cyclizes favorably to the aryl ring that is cis to it. The main advantages of this method include good functional group tolerance and the transition-metal-free characteristic. The Royal Society of Chemistry 2013.
- Li, Jinming,Chen, Huiyu,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang
-
p. 4311 - 4320
(2013/04/24)
-
- Novel process for the synthesis of class I antiarrhythmic agent (±)-cibenzoline and its analogs
-
Synthesis of (±)-cibenzoline and its analogs has been achieved by a simple sequence of reactions. The diaryl cyanoolefin intermediate 3 could be prepared by Knoevenagel condensation of benzophenone with ethylcyanoacetate to form the tetra-substituted olefin intermediate 2 followed by Krapcho deethoxycarbonylation or from β-hydroxynitrile intermediate 2' followed by the elimination of hydroxyl group respectively. The 2,2- diphenylcyclopropanecarbonitrile 4 was synthesized from intermediate 3 by cyclopropanation, which was converted to (±)-2-(2,2-diphenylcyclopropyl)- 2-imidazoline 5 by reaction with ethylenediamine in the presence of a catalytic amount of sulfur. Moreover, the obtained 2-imidazolines were smoothly oxidized to the corresponding imidazoles 6 in good to moderate yields. Copyright Taylor & Francis Group, LLC.
- Gholap, Atul R.,Paul, Vincent,Srinivasan, Kumar V.
-
p. 2967 - 2982
(2008/12/22)
-
- Photostable cosmetic screening composition containing a UV-A screening agent and an alkyl β, β-diphenylacrylate or α-cyano-β,β-diphenylacrylate
-
A photostable cosmetic screening composition and process for protection of the human epidermis against UV rays of wavelengths between 280 and 380 nm, the composition having, in a cosmetically acceptable vehicle containing at least one fatty phase, 1 to 5% by weight of a dibenzoylmethane derivative and at least 1% by weight of an alkyl β-β-diphenylacrylate or α-cyano-β-β-diphenylacrylate of formula (I), the mole ratio of the compound of formula (I) to the dibenzoylmethane derivative being not less than 0.8.
- -
-
-