cas 524718-27-2, 4-bromo-6-methylpyridin-2-amine

A series of 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and analogous quinolines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. 2-Hydroxyalkylamino substitution combines high affinity with selectivity (vs α1 and M1 receptors) and activity in vivo.

The invention relates to compounds of formulae Compounds of the invention have a good affinity to the NMDA receptor and are useful for the treatment of diseases related to this receptor.

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524718-27-2

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Chemical Properties

Boiling Point: 268 ?C

Flash Point:116 ?C

Density: 1.593

Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

PKA: 5.96±0.35(Predicted)

PSA: 39.64000

LogP: 1.66480

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