- Benzimidazolidinone derivatives as muscarinic agents
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Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
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Page/Page column 22
(2010/02/06)
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- N,N'-Linked 1,2-ethanediyl-poly(benzimidazolin-2-ones) and the X-ray crystal structure of a benzimidazolin-2-one trimer
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A series of N,N'-linked 1,2-ethanediyl-poly(benzimidazolin-2-ones) that can be classified as podands, are described. Seven dimers (21-27), three trimers (28-30), a cyclic tetramer (31) and an open-chain benzimidazolin-2-one heptamer (32) have been prepared and characterized by 1H, 13C NMR and by MS. The crystal and molecular structure of the trimer, 1,3-bis-2-(2-oxobenzimidazol-1-yl)ethyl-2-oxobenzimidazole monohydrate (30) has been solved by X-Ray analysis. The benzi-midazolin-2-one fragments display a pattern of bond distances and angles similar to that of analogue derivatives retrieved form the CSD. The molecules are hydrogen bonded to four others in a continuous two-dimensional network by N-H···O=C and C-H···O=C interactions in which all N-H donors and O=C accepters are involved.
- Diez-Barra, Enrique,Dotor, Julio,De La Hoz, Antonio,Foces-Foces, Concepcion,Enjalbal, Christine,Aubagnac, Jean Louis,Claramunt, Rosa Maria,Elguero, Jose
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p. 7689 - 7704
(2007/10/03)
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