- A pharmaceutical intermediate liu Anfen N-P-hydroxy phenyl salicylic amide synthesis method (by machine translation)
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A pharmaceutical intermediate liu Anfen N-P-hydroxy phenyl salicylic amide synthesis method, comprising the following steps: in the reaction container to aminophenol 0.07mol, 2-hydroxy-benzamide 0.074 the [...] 0.076mol, ethyl acetate the 70 [...] 80 ml, control the stirring speed in the 110 [...] 150rpm, slowly adding stannous chloride 0.031mol, darkening solution, after adding slowly increasing the temperature to 160 - - 170°C, reaction 5 the [...] 6h, vacuum distillation, boil off some ethyl acetate, reducing the temperature of the solution to 35 - - 38°C, the reactants are poured into a 500 ml in sodium bisulfite solution, layering, layer plus molecular sieve decolourizations, filtering, the filtrate by adding oxalic acid solution, adjusting the pH to 3 the [...] 4, separating solid, re-crystallization in the ethylenediamine solution, the white solid obtained N-P-hydroxy phenyl salicylic amide; wherein the step of pressure at the pressure of the distillation the 1.9 [...] 2.1kPa. (by machine translation)
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Paragraph 0006; 0014; 0015
(2016/11/17)
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- Synthesis, antimicrobial, and QSAR studies of substituted benzamides
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A series of new substituted benzamides were synthesized and tested in vitro for their antibacterial activity against Gram-positive and Gram-negative bacteria and as well for antifungal activity. The compounds 8i and 9 showed better activity among the different benzamides synthesized. The structural characteristics governing antibacterial activities of substituted benzamides were studied using QSAR methodology. The results showed that the antimicrobial activity could be modeled using the topological descriptors, molecular connectivity indices (2χv and 2χ) and Kiers shape index (κα1). The low residual activity and high cross-validated r2 values (rcv2) observed indicated the predictive ability of the developed QSAR models.
- Kumar, Anil,Narasimhan, Balasubramanian,Kumar, Devinder
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p. 4113 - 4124
(2008/03/11)
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