- Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives
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The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, R1, R2, A and n are as defined in the specification and to their pharmaceutically active salts. The invention also relates to novel compounds of formula I, pharmaceutical compositions containing them, and methods for their preparation.
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Page/Page column 43; 44
(2010/11/28)
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- Benzylamidine derivatives with serotonin receptor binding activity
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This invention relates to compounds having serotonin receptor binding activity, to pharmaceutical compositions containing them and to their medical use, particularly in the treatment of CNS conditions. Described herein are compounds which have the general formula: STR1 wherein R 1 is selected from a group of Formula i and ii: STR2 n is 1-3; R 2 is selected from H and C 1-6 alkyl;R 3 is selected from H and C 1-6 alkyl;R 4 is selected from C 1-6 alkyl, halo, phenyl, amino and nitro;R 5 is selected from H, C 1-6 alkyl and arylalkyl;R 6 is selected from H or a alkylene group which is bonded to R 4 to form the naphthalene ring skeleton; and salts, hydrates and solvates thereof.Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of subtypes of the serotonin receptor is implicated, such as migraine.
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- Feed additive for improving growth in agricultural animals
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By using α-mimetics, particularly compounds of general formulae I to III and the compounds listed in Table I, as feed additives in fattening animals, it has surprisingly been possible to improve the daily weight gain, the utilisation of fodder and the ratio of muscle to fat in favor of the proportion of muscle and protein.
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