- Triazolopyrimidine cannabinoid receptor 1 antagonists
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The present application describes compounds according to both Formulas I and II, pharmaceutical compositions comprising at least one compound according to either Formula I or II and optionally one or more additional therapeutic agents, and methods of treatment using the compounds according to Formulas I and II both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formulas: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein R1, R2, R3, R4 and R5 are described herein.
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Page/Page column 41
(2010/11/25)
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- Carbonylation of 2-chloro-4,6-dimethoxypyrimidine and 2-(chloromethyl)- 4,6-dimethoxypyrimidine
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The preparation of pyrimidine-2-carboxylates and 2-pyrimidineacetates by alkoxycarbonylation of respectively 2-chloropyrimidine and 2- (chloromethyl)pyrimidine with carbon monoxide in the presence of palladium acetate and 1,1'-bis(diphenylphosphino)ferroc
- Bessard, Yves,Crettaz, Roger
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p. 405 - 412
(2007/10/03)
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- Process for the production of 4,6-dialkoxypyrimidines
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A process for the production of 4,6-dialkoxypyrimidines of the general formula: STR1 A propanediimidate of the general formula: STR2 is converted with an anhydride of the general formula: STR3 to provide the product.
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