Highly active nano-MgO catalyzed, mild, and efficient synthesis of amidines via electrophilic activation of amides
Nano-MgO catalyzed synthesis of amidine derivatives is developed under solvent-free reaction condition at 70 C. Reusability of the catalyst and shorter reaction time as well as high yields are the advantages of this procedure.
Das, Vijay Kumar,Thakur, Ashim Jyoti
p. 4164 - 4166
(2013/07/26)
Copper catalyzed N-arylation of amidines with aryl boronic acids and one-pot synthesis of benzimidazoles by a Chan-Lam-Evans N-arylation and C-H activation/C-N bond forming process
Mono-N-arylation of benzamidines 1 with aryl boronic acids 2 was effectively achieved in the presence of a catalytic amount of Cu(OAc) 2 and NaOPiv under mild aerobic conditions. Combining this step with an intramolecular direct C-H bond functionalization, catalyzed by the same catalytic system but under oxygen at 120 C, afforded benzimidazoles 3 in good to excellent yields.
Efficient microwave access to polysubstituted amidines from imidoylbenzotriazoles
Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields. Convenient preparations of a variety of amides 5a-Ab (87-96%) and imidoylbenzotriazoles 6a-w (56-95%) have also been developed using microwave irradiation under mild conditions and short reaction times. These results demonstrate further the advantages of microwave synthesis and introduce a new application of imidoylbenzotriazoles in the preparation of polysubstituted amidines.
Katritzky, Alan R.,Cai, Chunming,Singh, Sandeep K.
p. 3375 - 3380
(2007/10/03)
Extraction-spectrophotometric determination of rhenium(VII) with thiocyanate and amidines in the presence of cetyltrimethylammonium bromide
A simple and selective spectrophotometric method has been developed for the determination of rhenium(VII) in the ore sample based on the reaction of ReVII with thiocyanate in the presence of tin(II) chloride in sulfuric acid media and subsequent extraction of the complex with chloroform solution of N,N′-diphenylbenzamidine (DPBA) and its nine derivatives in the presence of a cationic surfactant, cetyltrimethylammonium bromide (CTAB). The effects of acids and organic solvents on the extraction of the metal and colour intensity of the complex are discussed. The tolerance limits of diverse ions are very high. MoVI interferes it but is removed by prior precipitation by oxine effectively. The molar absorptivity and detection limit of the method with DPBA are (3.65 ± 0.02) × 104 dm -3 mol-1 cm-1 and 0.004 μg ml-1, respectively. The relative standard deviation of the method at a level of 25 μg ReVII / 10 ml is ± 1.2%.
Deb, Manas Kanti,Shrivastava, Mona
p. 388 - 389
(2007/10/03)
Reaction of N,N-Dimethyl-N'-thiobenzoylformamidine and N,N-Dimethyl-N'-phenylthiocarbamoylformamidine with N-Arylbenzimidoyl Chlorides
The reactions of N,N-dimethyl-N'-thiobenzoylformamidine (1) and N,N-dimethyl-N'-phenylthiocarbamoylformamidine (4) with N-arylbenzimidoyl chlorides (2) have been studied.Compound 1 reacts with 2 in dry chloroform at room temperature to give dimidoyl sulphides (3) in good yields.However, the reaction of 2 with 4 in dry tetrahydrofuran under reflux results in the formation of a mixture of thiobenzanilides (5) and N-aryl-N'-phenylbenzamidines (6).Possible mechanistic pathways for these reactions have been suggested.
Baruah, P. D.,Roy, G.,Satsangi, R.,Mahajan, M. P.
p. 357 - 359
(2007/10/02)
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