- Catalysis with inorganic cations. VII. The catalytic process of the Diels-Alder reaction with magnesium perchlorate in CH2Cl2: Kinetic investigation and spectroscopic detection of the complexed intermediate
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The 2-arylidene-malonic acid dimethyl ester is a dienophile suitable to be coordinated by Mg(II). The formation of the dienophile/cation complex in a ratio 2:1 in a non-coordinating solvent has been demonstrated by NMR spectroscopy. Kinetic determinations performed in dichloromethane evidenced the high reactivity of the system. The high affinity for Mg(II) of the reacting dienophile allows the reaction to be performed under catalytic conditions, whose single steps have been clarified by both spectroscopic and kinetic methods.
- Desimoni, Giovanni,Faita, Giuseppe,Mella, Mariella,Ricci, Marina,Righetti, PierPaolo
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Read Online
- Catalysis with inorganic cations. VIII. Macrocyclic-yliden malonates: Synthesis, spectroscopic investigation, and metal perchlorate catalysis of the Diels-Alder reaction
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Macrocyclic-yliden malonates 8-10 have been prepared by Knoevenagel condensation of differently sized crown malonates 5-7 with several aldehydes. The spectroscopic investigations of derivatives 8-10a in several solvents (acetone, acetonitrile, and dichlor
- Desimoni, Giovanni,Faita, Giuseppe,Ricci, Marina,Righetti, PierPaolo
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Read Online
- A novel sublimable organic salt: Synthesis, characterization, thermal behavior, and catalytic activity for the synthesis of arylidene, heteroarylidene, and alkylidene malonates
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A novel sublimable organic salt was synthesized, and its chemical structure was characterized by FTIR, 1D NMR, 2D NMR, and elemental analysis. In addition, the thermal phase transitions and thermal stability of new organic salt were investigated. The DSC and TGA results showed that the organic salt could convert into constituent molecules at dec. ~ 200?°C) under atmospheric pressure without forming the liquid phase. Then, it was recondensed to regenerate the initial organic salt in the cool part of the vial. Therefore, it can be a promising organic salt towards the regeneration of spent catalyst from synthesis processes when the reaction mixture contains poorly volatile components and includes its use in gas-phase procedures. Also, the catalytic efficiency of new organic salt was investigated in the Knoevenagel condensation reaction. A variety of substituted arylidene and alkylidene malonates were isolated in 78–95% yield within six hours.? Under the optimized reaction conditions, the current catalytic procedure exhibited superiority compared to the mixed piperazine/acetic acid, piperidine/acetic acid, and piperidinium acetate. There were no significant changes in the new organic salt chemical structure and catalytic activity even after the 5th run. This work revealed the importance of the existence of simultaneous hydrogen bond acceptor/donor groups in our environmentally friendly catalyst to promote the Knoevenagel condensation reaction without the use of metal-containing catalysts.
- Johari, Suzaimi,Zaharani, Lia,Gorjian, Hayedeh,Johan, Mohd R.,Khaligh, Nader G.
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p. 361 - 377
(2021/09/18)
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- Solid-phase synthesis of arylidene and alkylidene malonates, as versatile intermediates, catalyzed using mesoporous poly-melamine–formaldehyde as a nitrogen-rich porous organic polymer (POP)
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An efficient solid/slurry-state synthesis of arylidene and alkylidene malonates as versatile intermediates is developed in the presence of mesoporous poly-melamine–formaldehyde. The condensation reaction was conducted through a ball milling process as a non-conventional procedure and a greener methodology at room temperature under solvent-free conditions. The mesoporous heterogeneous catalyst could be recovered and reused ten times, and the results showed a negligible loss of catalytic activity. Various aryl- and heteroarylidene malonates, as well as dimethyl (cyclohexylidene)malonate, were isolated in good to high yields under optimal conditions. The use of hazardous reagents and solvents were minimized in the current method, and separation of catalyst and products, as well as the recovery and reusing of catalyst, were performed by cost-effective procedures. This work revealed that the synergistic effect of numerous Lewis base sites together with acceptor-donner hydrogen bonding functional groups in porous organic polymer (POP), and its high porosity plays a vital role to promote the carbon–carbon coupling reaction in the solid phase synthesis.
- Khaligh, Nader Ghaffari,Gorjian, Hayedeh,Fahim, Hoda,Titinchi, Salam J. J.
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p. 3529 - 3536
(2021/05/11)
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- Reductive Knoevenagel Condensation with the Zn-AcOH System
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An efficient gram-scale one-pot approach to 2-substituted malonates and related structures is developed, starting from commercially available aldehydes and active methylene compounds. The technique combines Knoevenagel condensation with the reduction of the C=C bond in the resulting activated alkenes with the Zn-AcOH system. The relative ease with which the C=C bond reduction occurs can be traced to the accepting abilities of the substituents in the intermediate arylidene malonates.
- Ivanov, Konstantin L.,Melnikov, Mikhail Ya.,Budynina, Ekaterina M.
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p. 1285 - 1291
(2020/11/13)
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- Asymmetric catalytic [4+3] cycloaddition ofortho-quinone methides with oxiranes
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Catalytic enantioselective [4+3] cycloaddition reaction betweeno-quinone methides and oxiranes was achieved by using a chiralN,N′-dioxide/TbIIIcomplex as the catalyst, affording medium-sized hydrodioxepine derivatives in high yields (up to 99%)
- Tan, Qingfa,Yu, Han,Luo, Yao,Chang, Fenzhen,Liu, Xiaohua,Zhou, Yuqiao,Feng, Xiaoming
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supporting information
p. 3018 - 3021
(2021/03/29)
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- Cross-linked polystyrene-TiCl4 complex as a reusable Lewis acid catalyst for solvent-free Knoevenagel condensations of 1,3-dicarbonyl compounds with aldehydes
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Cross-linked polystyrene copolymer beads with the average particle size in the range of (50–80 mesh size) were prepared by a new method, characterized and functionalized with titanium tetrachloride to afford the corresponding polystyrene?titanium tetrachloride complex in one step reaction and characterized by FT-IR, UV, TGA, DSC, XRD, SEM, BET. This polymer metal complex (PS/TiCl4) was used as a heterogeneous, recoverable, reusable Lewis acid for solvent-free Knoevenagel condensations of 1,3-diketones with aromatic aldehydes under green and mild conditions. The rate of reactions was found to decrease with an increasing percentage of crosslinking and the mesh size of the copolymer beads. This complex showed good stability and catalytic activity in the Knoevenagel reactions.
- Rahmatpour, Ali,Goodarzi, Niloofar
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- Stereospecific copper(II)-catalyzed tandem ring opening/oxidative alkylation of donor-acceptor cyclopropanes with hydrazones: Synthesis of tetrahydropyridazines
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Aerobic copper(II)-catalyzed tandem ring opening and oxidative C-H alkylation of donor-acceptor cyclopropanes with bisaryl hydrazones is accomplished to produce tetrahydropyridazines, in which copper(II) plays dual role as a Lewis acid as well as redox catalyst. The reaction is stereospecific, and optically active cyclopropanes can be reacted with high optical purities (89-98% enantiomeric excess). The substrate scope, functional group tolerance, dual role of the copper(II) catalyst, and the use of air as an oxidant are the important practical features. A product bearing a 3-bromoaryl group can be subjected to Pd-catalyzed Suzuki coupling with boronic acid in high yield.
- Mishra, Manmath,De, Pinaki Bhusan,Pradhan, Sourav,Punniyamurthy, Tharmalingam
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p. 10901 - 10910
(2019/09/13)
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- An Expeditious Route to trans-Configured Tetrahydrothiophenes Enabled by Fe(OTf)3-Catalyzed [3+2] Cycloaddition of Donor–Acceptor Cyclopropanes with Thionoesters
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A synthetic route to trans-configured tetrahydrothiophenes (THTs) through Fe(OTf)3-promoted [3+2] cycloaddition of donor–acceptor cyclopropanes with thionoesters was developed. The cycloaddition proceeded in high yield with high diastereoselectivity, affording transient α-alkoxy THTs. Not only aromatic and aliphatic thionoesters, but also thionolactone were applicable to the present iron catalysis. Further transformation of the S,O-ketal functionality of the product was achieved in a highly trans diastereoselective manner. Moreover, the utility of our methodology was clearly demonstrated by the synthesis of enantioenriched trans-configured THTs.
- Matsumoto, Yohei,Nakatake, Daiki,Yazaki, Ryo,Ohshima, Takashi
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supporting information
p. 6062 - 6066
(2018/03/28)
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- Nucleophilic Ring Opening of Donor-Acceptor Cyclopropanes Catalyzed by a Br?nsted Acid in Hexafluoroisopropanol
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A general, Br?nsted acid catalyzed method for the room temperature, nucleophilic ring opening of donor-acceptor cyclopropanes in fluorinated alcohol solvent, HFIP, is described. Salient features of this method include an expanded cyclopropane scope, including those bearing single keto-acceptor groups and those bearing electron-deficient aryl groups. Notably, the catalytic system proved amenable to a wide range of nucleophiles including arenes, indoles, azides, diketones, and alcohols.
- Richmond, Edward,Vukovi?, Vuk D.,Moran, Joseph
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supporting information
p. 574 - 577
(2018/02/10)
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- Intermolecular Reductive Couplings of Arylidene Malonates via Lewis Acid/Photoredox Cooperative Catalysis
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A cooperative Lewis acid/photocatalytic reduction of arylidene malonates yields a versatile radical anion species. This intermediate preferentially undergoes intermolecular radical-radical coupling reactions, and not the conjugate addition-dimerization reactivity typically observed in the single-electron reduction of conjugate acceptors. Reported here is the development of this open-shell species in intermolecular radical-radical cross couplings, radical dimerizations, and transfer hydrogenations. This reactivity underscores the enabling modularity of cooperative catalysis and demonstrates the utility of stabilized enoate-derived radical anions in intermolecular bond forming reactions.
- McDonald, Benjamin R.,Scheidt, Karl A.
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supporting information
p. 6877 - 6881
(2018/11/02)
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- Scandium(III) Trifluoromethanesulfonate Catalyzed Selective Reactions of Donor–Acceptor Cyclopropanes with 1,1-Diphenylethanols: An Approach to Polysubstituted Olefins
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An unexpected synthetic approach to polysubstituted olefins through the scandium(III) trifluoromethanesulfonate catalyzed ring-opening reaction of donor–acceptor cyclopropanes with 1,1-diphenylethanols was developed. The reactions, which are experimentally easy to handle, feature tolerance of various functional groups and mild reaction conditions. On the basis of experimental evidence, a plausible mechanism was also proposed.
- Zhu, Xiaoyan,Hong, Gang,Hu, Chen,Wu, Shengying,Wang, Limin
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supporting information
p. 1547 - 1551
(2017/04/01)
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- Cascade One-Pot Synthesis of Indanone-Fused Cyclopentanes from the Reaction of Donor-Acceptor Cyclopropanes and Enynals via a Sequential Hydrolysis/Knoevenagel Condensation/[3+2] Cycloaddition
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A cascade reaction of donor-acceptor cyclopropanes with enynals to construct indanone-fused cyclopentanes via a sequential hydrolysis/Knoevenagel condensation/[3+2] cycloaddition is reported. The desired indanone-fused cyclopentanes were obtained in good yields. This method features mild reaction conditions and broad substrate scope, which render it very appealing to chemists for the synthesis of complex molecules containing an indanone-fused cyclopentane moiety. Moreover, the products could be further converted into compounds with different functional groups through the well-known transformations. (Figure presented.).
- Zhang, Jiantao,Jiang, Huanfeng,Zhu, Shifa
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supporting information
p. 2924 - 2930
(2017/09/08)
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- Indium(III)-catalyzed knoevenagel condensation of aldehydes and activated methylenes using acetic anhydride as a promoter
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The combination of a catalytic amount of InCl3 and acetic anhydride remarkably promotes the Knoevenagel condensation of a variety of aldehydes and activated methylene compounds. This catalytic system accommodates aromatic aldehydes containing a variety of electron-donating and -withdrawing groups, heteroaromatic aldehydes, conjugate aldehydes, and aliphatic aldehydes. Central to successfully driving the condensation series is the formation of a geminal diacetate intermediate, which was generated in situ from an aldehyde and an acid anhydride with the assistance of an indium catalyst.
- Ogiwara, Yohei,Takahashi, Keita,Kitazawa, Takefumi,Sakai, Norio
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p. 3101 - 3110
(2015/03/30)
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- Efficient synthesis of β-aryl-γ-lactams and their resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen
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An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained, followed by the reduction of the γ-nitroester in the presence of Raney nickel and the subsequent saponification/decarboxylation reaction. The utility of this methodology was highlighted by the preparation of enantiomerically-pure (R)- and (S)-Baclofen hydrochloride.
- Montoya-Balbás, Iris J.,Valentín-Guevara, Berenice,López-Mendoza, Estefanía,Linzaga-Elizalde, Irma,Ordo?ez, Mario,Román-Bravo, Perla
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p. 22028 - 22043
(2016/01/25)
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- Triflic Acid Catalyzed Formal [3 + 2] Cycloaddition of Donor-Acceptor Oxiranes and Nitriles: A Facile Access to 3-Oxazolines
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A TfOH-catalyzed chemoselective [3 + 2] cycloaddition of donor-acceptor oxiranes and nitriles is described. This reaction provides an efficient and practical method for the preparation of useful 3-oxazolines in good to excellent yields (up to 99%).
- Zhou, Hai,Zeng, Xiaofei,Ding, Liyuan,Xie, Yan,Zhong, Guofu
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supporting information
p. 2385 - 2387
(2015/05/27)
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- Synthesis of 3-Oxazolines via SnCl4-Promoted Formal [3+2] Cycloaddition of Donor-Acceptor Oxiranes and Nitriles
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A novel SnCl4-promoted formal [3+2] cycloaddition of donor-acceptor oxiranes and nitriles via chemoselective C-C bond breakage was developed. This reaction provides an efficient and practical method for the preparation of 3-oxazolines in good yields (up to 89%).
- Zhou, Hai,Zeng, Xiaofei,Xie, Yan,Zhong, Guofu
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supporting information
p. 1693 - 1696
(2015/07/20)
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- A new type of donor-acceptor cyclopropane reactivity: The generation of formal 1,2- and 1,4-dipoles
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A new type of donor-acceptor cyclopropane reactivity has been discovered. On treatment with anhydrous GaCl3, they react as sources of even-numbered 1,2- and 1,4-dipoles instead of the classical odd-numbered 1,3-dipoles due to migration of positive charge from the benzyl center. This type of reactivity has been demonstrated for new reactions, namely, cyclodimerizations of donor-acceptor cyclopropanes that occur as [2+2]-, [3+2]-, [4+2]-, [5+2]-, [4+3]-, and [5+4]-annulations. The [4+2]-annulation of 2-arylcyclopropane-1,1-dicarboxylates to give polysubstituted 2-aryltetralins has been developed in a preparative version that provides exceedingly high regio- and diastereoselectivity and high yields. The strategy for selective hetero-combination of donor-acceptor cyclopropanes was also been developed. The mechanisms of the discovered reactions involving the formation of a comparatively stable 1,2-ylide intermediate have been studied. Old ring, new reactivity: A new type of donor-acceptor cyclopropane reactivity has been discovered. On treatment with anhydrous GaCl3, they react as sources of even-numbered 1,2- and 1,4-dipoles instead of the classical odd-numbered 1,3-dipoles owing to the migration of positive charge from the benzyl center.
- Novikov, Roman A.,Tarasova, Anna V.,Korolev, Victor A.,Timofeev, Vladimir P.,Tomilov, Yury V.
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supporting information
p. 3187 - 3191
(2014/04/03)
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- TiCl4 promoted formal [3 + 3] cycloaddition of cyclopropane 1,1-diesters with azides: Synthesis of highly functionalized triazinines and azetidines
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A TiCl4 promoted formal [3 + 3] cycloaddition of cyclopropane 1,1-diesters with azides has been developed for the synthesis of highly functionalized triazinines. Both stoichiometric and substoichiometric versions of this reaction were accomplished dependent on the choice of solvent. It is noteworthy that the corresponding products could be easily converted to biologically important azetidines by simple thermolysis.
- Zhang, Huan-Huan,Luo, Yong-Chun,Wang, Hua-Peng,Chen, Wei,Xu, Peng-Fei
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supporting information
p. 4896 - 4899
(2015/04/27)
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- Organocatalytic knoevenagel condensations by means of carbamic acid ammonium salts
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The Knoevenagel condensation between an active methylene compound and an aromatic aldehyde with a carbamic acid ammonium salt used as an organocatalyst gave the desired Knoevenagel products in up to 98% yield. The reaction occurred at rt and in a short reaction time under solvent-free conditions. In addition, no extraction, wash, or chromatography steps were needed to obtain a high-purity Knoevenagel product.
- Mase, Nobuyuki,Horibe, Takuya
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supporting information
p. 1854 - 1857
(2013/06/04)
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- Iodine-promoted synthesis of 3-arylindolizine-1-carboxylates from 2-(2-nitro-1-arylethyl)malonates and pyridine
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An efficient and straightforward one-pot synthetic protocol has been developed for the synthesis of 3-arylindolizine- 1-carboxylates via 1,3-dipolar annulation of 2-(2-nitro-1-arylethyl)malonates with pyridine and subsequent aromatisation in the presence of molecular iodine. The structure of methyl 3-(4-methoxyphenyl)indolizine-1-carboxylate (2a) and methyl 3-iodo-2-(4- nitrophenyl)indolizine-1-carboxylate (2f) was further confirmed by X-ray single crystal analysis. Website
- Li, Yun,Zhou, Zhengquan,Ye, Weijian,Liu, Juanjuan,Yao, Juan,Wang, Cunde
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p. 526 - 530
(2013/10/22)
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- Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors
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Inhibition of TLR4 signaling is an important therapeutic strategy for intervention in the etiology of several pro-inflammatory diseases. There has been intensive research in recent years aiming to explore this strategy, and identify small molecule inhibitors of the TLR4 pathway. However, the recent failure of a number of advanced drug candidates targeting TLR4 signaling (e.g., TAK242 and Eritoran) prompted us to continue the search for novel chemical scaffolds to inhibit this critical inflammatory response pathway. Here we report the identification of a group of new TLR4 signaling inhibitors through a cell-based screening. A series of arylidene malonate analogs were synthesized and assayed in murine macrophages for their inhibitory activity against LPS-induced nitric oxide (NO) production. The lead compound 1 (NCI126224) was found to suppress LPS-induced production of nuclear factor-kappaB (NF-κB), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and nitric oxide (NO) in the nanomolar-low micromolar range. Taken together, this study demonstrates that 1 is a promising potential therapeutic candidate for various inflammatory diseases.
- Zhang, Shuting,Cheng, Kui,Wang, Xiaohui,Yin, Hang
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p. 6073 - 6079
(2012/11/07)
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- C-O versus C-C bond cleavage: Selectivity control in Lewis acid catalyzed chemodivergent cycloadditions of aryl oxiranyldicarboxylates with aldehydes, and theoretical rationalizations of reaction pathways
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A clean break: Lewis acid catalyzed chemodivergent [3+2] cycloadditions of aryl oxiranyldicarboxylates with aldehydes are revealed, in which the C-C or C-O bond cleavage of oxiranes can be controlled by the use of Ni(ClO 4)2 or Sn(OTf)2 catalysts (see scheme). Possible reaction pathways for these transformations are demonstrated by theoretical calculations. Copyright
- Chen, Zuliang,Tian, Ziqi,Zhang, Jieming,Ma, Jing,Zhang, Junliang
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supporting information; experimental part
p. 8591 - 8595
(2012/08/13)
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- Stereoselective double lewis acid/organo-catalyzed dimerization of donor-acceptor cyclopropanes into substituted 2-oxabicyclo[3.3.0]octanes
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A new approach for the dimerization of donor-acceptor cyclopropanes (2-arylcyclopropane-1,1-dicarboxylates) under double-catalysis conditions by treatment with 20 mol % of GaCl3 and dimethyl 3,5-dimethyl-1- pyrazoline-3,5-dicarboxylate as a specific organocatalyst has been found. Under these conditions, the starting compounds are regio- and stereospecifically converted into polysubstituted 2-oxabicyclo[3.3.0]octanes. Two new rings, one C-O bond, and two C-C bonds are formed in this process, and four stereocenters are thus created. The reaction mechanism was thoroughly studied by NMR spectroscopy, and a number of intermediates were detected.
- Novikov, Roman A.,Timofeev, Vladimir P.,Tomilov, Yury V.
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experimental part
p. 5993 - 6006
(2012/10/08)
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- Asymmetric michael addition of ketones to alkylidene malonates and allylidene malonates via enamine - Metal lewis acid bifunctional catalysis
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Novel enamine-metal Lewis acid bifunctional catalysts were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99% ee and >99:1 dr). The asymmetric Michael addition of ketones to allylidene malonates was also achieved.
- Liu, Lu,Sarkisian, Ryan,Xu, Zhenghu,Wang, Hong
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supporting information
p. 7693 - 7699
(2012/11/07)
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- Phosphine-catalyzed [4+2] annulations of 2-alkylallenoates and olefins: Synthesis of multisubstituted cyclohexenes
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From our investigations on phosphine-catalyzed [4+2] annulations between α-alkyl allenoates and activated olefins for the synthesis of cyclohexenes, we discovered a hexamethylphosphorous triamide (HMPT)-catalyzed [4+2] reaction between α-alkyl allenoates
- Tran, Yang S.,Martin, Tioga J.,Kwon, Ohyun
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body text
p. 2101 - 2106
(2011/10/11)
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- Condensation of dimethyl malonate with benzal-4-acetyIanilines: A chemoselective reaction
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Dimethyl malonate has reacted chemoselectively with carbon- nitrogen double bond of benzal-4-acetylanilines (1-8) leaving the carbon-oxygen double bond, considered to be more reactive, intact under reaction conditions, leading to the formation of mono addition-elimination products rather than bis attack at both the double bonds, even when the reaction has been carried out with two moles of dimethyl malonate.
- Sidhu, Anjali,Rai, Mangat
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experimental part
p. 735 - 736
(2009/12/24)
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- Clay-mediated Synthesis of gem-Bis(alkoxycarbonyl) Alkenes under Microwave Irradiation
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Diethyl and dimethyl malonate react selectively with aldehydes to afford alkenes within a few minutes, by adsorption on acidic clay (Montmorillonite K10) in a solvent-free reaction under microwave irradiation in a domestic oven.
- Ayoubi, Sahar Abdallah-El,Texier-Boullet, Francoise
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p. 208 - 209
(2007/10/03)
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- Reactions of diazocompounds with carbonyl compounds mediated by diorganyl telluride and catalytic amount of CuI compounds: Conversion of aldehydes to a
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A one-pot reaction of diorganyl telluride, diazo-compounds including dimethyl diazomalonate and ethyl diazoacetate, carbonyl compound and catalytic amount of Cu(I)I afforded the olefination products in high yields. The reaction is proposed to be through diorganyltelluronium bis (methoxycarbonyl)methylide and (ethoxycarbonyl)methylide respectively.
- Zhou, Zhang-Lin,Huang, Yao-Zeng,Shi, Li-Lan
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p. 6821 - 6830
(2007/10/02)
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- Isoxazolidine compounds, XI: 2,2-dialkyl-3-aryl-5-oxoisoxazolidinium salts: Cyclic analogues of Polonovski intermediates
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The 2-methyl-3-aryl-5-oxoisoxazolidines 1 are quaternized with 'magic methyl' or triethyloxonium tetrafluoroborate, respectively. The very sensitive cations 2 and 3, respectively, undergo easily solvolysis in methanol without recognizable Polonovski rearrangement.
- Steudle,Stamm
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p. 329 - 331
(2007/10/02)
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- A novel olefination of diazo-compounds with carbonyl compounds mediated by tributylstibine and catalytic amount of Cu(I)I
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A one-pot reaction of tributylstibine, diazo-compounds including dimethyl diazomalonate, ethyl diazoacetate and diazoacetylacetone, carbonyl compounds and catalytic amount of Cu(I)I resulted in olefination in high yields.
- Liao,Huang
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p. 5897 - 5900
(2007/10/02)
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- Utilisation of 13C N.M.R. Spectroscopy for the Identification of E- and Z-α,β-Unsaturated Esters, Ketones and Nitriles.
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Measurement of 3JCO,H coupling constants provides an unambiguous procedure for the configurational analysis of substituted 2- and 3-arylpropenoic esters and of E- and Z-2-arylbut-2-en-1,4-dioates, even when only one of the isomers is available for analysis.An analogous procedure can also be used for the configurational analysis of 3-arylpropenonitriles and of 4-arylbut-3-en-2-ones.
- Gregory, Barrie,Hinz, Werner,Jones, R. Alan,Arques, Jose Sepulveda
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p. 2801 - 2821
(2007/10/02)
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