Synthesis and cytotoxicity of a novel 1-alkylaminomethyl-2,4-diaryl- butadiene-1,3 fragment integrated within cyclohex(pent)enes
A group of 1-alkylaminomethyl-2-aryl-3-arylidenecyclohex(pent)enes 3a-n with a 1-alkylaminomethyl-2,4-diaryl-1,3-butadiene fragment and a group of their congeners 3-alkylaminomethyl-1,2-diarylcyclohexene 7a-f have been synthesised for the first time. The conjugated system in 1-alkylaminomethyl-2-aryl-3- arylidenecyclohex(pent)enes 3a-n was unambiguously confirmed by X-ray crystallography. Cytotoxicity tests revealed that 3a-n possess inconsistent cytotoxicity against cancer cells, not their congeners 7a-f.
Zhao, Kejun,Wang, Yongfeng,Zhao, Linxiang,Ji, Zhizhong,Li, Dan,Tisdale, Michael J.,Schwalbe, Carl H.
p. 373 - 379
(2007/10/03)
Study of the Neber Rearrangement of 2-Phenylcyclohexanone Dimethylhydrazone Methiodide. An Alternnative Ylide Pathway Leading to the Formation of Mannich Products
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Parcell, Robert F.,Sanchez, Joseph P.
p. 5229 - 5231
(2007/10/02)
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