Substituted heterocyclic compound as well as derivative, medicinal composition, preparation method and application thereof
The invention provides a substituted heterocyclic compound as well as a preparation method and application thereof, particularly a substituted heterocyclic compound as well as a derivative, a medicinal composition, a preparation method and application the
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Paragraph 0247; 0254; 0255; 0280
(2018/07/15)
Catalytic asymmetric hydrogenation of δ-ketoesters: Highly efficient approach to chiral 1,5-diols
High turnover: An highly efficient catalytic asymmetric hydrogenation of δ-aryl-δ-ketoesters has been realized by using the chiral spiroiridium catalyst (R)-1. Chiral 1,5-diol products are obtained with excellent enantioselectivity and turnover numbers (TONs) as high as 100 000. TOF=turnover frequency. Copyright
Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK1 Antagonists
(Equation presented) A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.
Reichard, Gregory A.,Stengone, Carmine,Paliwal, Sunil,Mergelsberg, Ingrid,Majmundar, Sapna,Wang, Cheng,Tiberi, Robert,McPhail, Andrew T.,Piwinski, John J.,Shih, Neng-Yang
p. 4249 - 4251
(2007/10/03)
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