- FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
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This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.
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Paragraph 0555-0556
(2021/01/29)
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- Transition-metal-catalyzed chemoselective methylenation of dicarbonyl substrates
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(Chemical Equation Presented) Rhodium- and copper-catalyzed methylenation reactions with trimethylsilyldiazomethane, triphenylphosphine, and 2-propanol were used to react chemoselectively with aldehydes, alkoxymethylketones, and triftuoromethylketones in substrates also containing a less reactive carbonyl group. Terminal alkenes were obtained in high yields, and no protecting group was necessary in the methylenation process.
- Lebel, Helene,Davi, Michael,Stoklosa, Grzegorz T.
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p. 6828 - 6830
(2008/12/22)
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- Synthesis and Properties of 4,4,9,9-Tetramethylparacyclophane-5,6,7,8-tetrone
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The synthesis of 4,4,9,9-tetramethylparacyclophane-5,6,7,8-tetrone (26) has been achieved in a multistep procedure.Compound 26 is the first cyclic tetraketone whose structure has been studied by X-ray analysis.The key intermediates were 4,4,9,9-tetramethylparacyclophane-6,7-dione (22), 6,7-bis-4,4,9,9-tetramethylparacyclophane-5,7-diene (24), and two epimeric 5,8-dihydroxy-4,4,9,9-tetramethylparacyclophane-6,7-diones 25a and 25b.X-ray analyses have been performed on 24, 25b and 26.That on 24 reveals a dihedral angle of 57 deg between the two silyenol ether groups.The product analyses and the configurations of 25a and 25b together with the isolation of the bis(epoxide) intermediate 28 allow conclusions to be drawn on the oxidation mechanism of 24 with m-CPBA (Rubottom reaction).The stability of 26 is ascribed to steric factors.
- Gleiter, Rolf,Kraemer, Rolf,Irngartinger, Hermann,Bissinger, Claus
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p. 252 - 258
(2007/10/02)
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- Aromatic Spiranes, XIV: Syntheses of 2,2'-Spirobi-(s-hydrindacene) and its precursors
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The title compound 35 was prepared by catalytic reduction of the diones 29a and 11a. 29a was synthesized by systematic anellation of fivemembered rings to the positions 5,6 and 5',6', resp., of 2,2'-spirobiindane.The preparation of 11a was achieved by Friedel-Crafts cyclisation of bis-(5-indanylmethyl)-malonic acid. s-Hydrindacene-1-one 5a was prepared as a precursor for the synthesis of 11a (see forthcoming publication) and its derivates as models for corresponding anellation and substitution reactions. - Keywords: s-Hydrindacene-1-one and derivates; Mono- and bisanellation; 2,2'-Spirobiindane; 1H-nmr spectra
- Neudeck, Horst K.
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p. 627 - 658
(2007/10/02)
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