Useful four-carbon synthons en route to monastrol analogs
A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were further elaborated to analogs of monastrol having variant ester sidechains, that were evaluated for their anticancer activity employing the NCI 60 cell line panel.
Abdou, Amr M.,Botros,Hassan, Rasha A.,Kamel, Mona M.,Taber, Douglass F.,Taher, Azza T.
p. 139 - 146
(2015/02/18)
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