- Copper-Catalyzed Oxidative Thioamination of Maleimides with Amines and Bunte Salts
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Herein, we describe the first example of copper-catalyzed oxidative thioamination of maleimides with secondary amines and Bunte salts with the achievement of C-N and C-S bonds in a single flask. The protocol showcases a prominently broad substrate scope a
- Shi, Shanshan,Ma, Yunfei,Zhou, Jun,Li, Jia,Chen, Luya,Wu, Ge
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- Oxidative Aminoarylselenation of Maleimides via Copper-Catalyzed Four-Component Cross-Coupling
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The first example of copper-catalyzed four-component coupling reaction of aryl iodides, Se powder, secondary amines, and maleimides is developed. This reaction provides an efficient and concise route to access aminoarylselenated maleimides via double C-Se bonds and C-N bond formation. The appealing features of this transformation are the use of Se powder as a selenating reagent, a green catalytic system, a wide range of substrate scope, and late-stage selenation of bioactive compounds.
- Gao, Xue,Tang, Liyang,Huang, Lehao,Huang, Zu-Sheng,Ma, Yunfei,Wu, Ge
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- Synthesis of novel N-aryl-3-dialkylamino-4-substituted maleimides
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The syntheses of several novel 3-dialkylamino-N-aryl-maleimides 3a-i and 6 are described via a conjugate elimination addition-elimination pathway. Syntheses of their various 4-substituted derivatives 4a-i, 5a-c and 7-12 are also described. Introduction of a secondary amino group at C-3 position in N-arylmaleimides leads to the formation of enaminones 3a-i and 6, which undergo facile electrophilic substitutions at C-4 position in good to excellent yields to provide the highly functionalized maleimides 4a-i, 5a-c and 7-12.
- Patil, Nilesh S.,Deshmukh, Ganesh B.,Mahale, Keshao A.,Gosavi, Kirankumar S.,Patil, Sambhaji V.
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p. 272 - 278
(2015/03/04)
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