- Total synthesis of the chlorinated marine natural product dysamide B
-
Two approaches to the synthesis of (2S,4S)-5,5-dichloroleucine are compared, and the parent amino acid was used in the first total synthesis of the polychlorinaled marine natural product, dysamide B. A key step was the lead tetraacetate-mediated decarboxylation of an α,α-dichloro acid in the presence of 1,4-cyclohexadiene to generate the dichloromethyl group.
- Durow, Amanda C.,Long, G. Cliona,O'Connell, Susan J.,Willis, Christine L.
-
p. 5401 - 5404
(2007/10/03)
-
- Novel formation and crystal structure of 2-(2,2,2-trifluoroethylidene)-6-trifluoro-methyl-2,3-dihydro-4H-1,4-oxazin-3- ones from N-acetyl-N-alkyl-α-amino acids
-
The title compounds (2a-g) were formed from N-acetyl-N-alkyl-α-amino acids (1a-g) on treatment with trifluoroacetic anhydride in the presence of pyridine. The structure of the product (2a) was determined by single crystal X-Ray analysis.
- Kawase, Masami,Saito, Setsuo,Kikuchi, Hiroyuki,Miyamae, Hiroshi
-
p. 2185 - 2195
(2007/10/03)
-
- Acyl derivatives
-
Peptide derivatives provided by the present invention are compounds of the general formula STR1 wherein R1 represents a hydrogen atom or the methyl or hydroxymethyl group or a mono-, di- or trihalomethyl mgroup; R2 represents the cha
- -
-
-